YIL781 [Ligand Id: 3538] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL243001 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847] | ||||||||
| GtoPdb | - | - | 7.77 | pKi | 17 | nM | Ki | Endocrinology (2007) 148: 5175-85 [PMID:17656463] |
| ChEMBL | Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting | B | 8.4 | pKi | 4 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 2271-2278 [PMID:22342626] |
| Ghrelin receptor in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5015] [UniProtKB: Q8MHZ5] | ||||||||
| ChEMBL | Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assay | B | 7.77 | pKi | 17 | nM | Ki | J Med Chem (2007) 50: 5202-5216 [PMID:17887659] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human Erg by patch clamp assay | B | 5.79 | pIC50 | 1621.81 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2271-2278 [PMID:22342626] |
| ChEMBL | Inhibition of human Erg by patch clamp assay | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2271-2278 [PMID:22342626] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Displacement of [125I]DIO from 5HT2c receptor | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2007) 50: 5202-5216 [PMID:17887659] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
