paroxetine [Ligand Id: 4790] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL490 (Pexeva, Paxil, Paxil [as hydrochloride], BRL 29060, BRL-29060, Paroxetine)
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  • beta adrenergic receptor kinase 1/G-protein coupled receptor kinase 2 in Human [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098]
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
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  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
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  • M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
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  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
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  • NK1 receptor/Neurokinin 1 receptor in Human [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
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  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
  • NET/Norepinephrine transporter in Mouse [ChEMBL: CHEMBL2370] [GtoPdb: 926] [UniProtKB: O55192]
  • Norepinephrine transporter in Rat [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
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  • Quinolone resistance protein norA in S.aureus [ChEMBL: CHEMBL5114] [UniProtKB: P0A0J7]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-adrenergic receptor kinase 1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3711550] [UniProtKB: P21146]
ChEMBL Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assay B 5.86 pIC50 1380 nM IC50 J Med Chem (2017) 60: 3052-3069 [PMID:28323425]
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
ChEMBL DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) B 6 pIC50 1000 nM IC50 DrugMatrix in vitro pharmacology data
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDAT B 6.31 pKd 490 nM Kd Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604]
ChEMBL DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) B 6.27 pKi 534 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL Binding inhibition towards human dopamine transporter B 6.4 pKi 400 nM Ki J. Med. Chem. (2005) 48: 6023-6034 [PMID:16162005]
ChEMBL DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) B 6.17 pIC50 672 nM IC50 DrugMatrix in vitro pharmacology data
DAT/Dopamine transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2799] [GtoPdb: 927] [UniProtKB: Q61327]
ChEMBL Tested in vitro for dopamine(DA) neuronal uptake inhibition B 6.34 pKi 460 nM Ki J. Med. Chem. (1990) 33: 2793-2797 [PMID:2213832]
ChEMBL Tested in vitro for serotonin(5-HT) neuronal uptake inhibition B 9.36 pKi 0.44 nM Ki J. Med. Chem. (1990) 33: 2793-2797 [PMID:2213832]
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL Inhibition of [3H]- DA reuptake into rat striatal synaptosomes B 5.77 pKi 1700 nM Ki Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604]
ChEMBL Inhibitory constant towards reuptake of [125I]-12 from dopamine transporter in rat striatal membranes B 6.4 pKi 400 nM Ki J. Med. Chem. (1994) 37: 1535-1542 [PMID:8182712]
ChEMBL Binding affinity against dopamine transporter (DAT) by displacement of [3H]WIN-35428 in male wistar rats B 6 pIC50 >1000 nM IC50 J. Med. Chem. (2003) 46: 5512-5532 [PMID:14640559]
ChEMBL Displacement of [3H]WIN-35428(0.5 nM) from Dopamine transporter B 6.21 pIC50 623 nM IC50 J. Med. Chem. (1998) 41: 247-257 [PMID:9457247]
beta adrenergic receptor kinase 1/G-protein coupled receptor kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098]
ChEMBL Inhibition of full length C-terminal hexahistidine tagged GRK2 (unknown origin) S670A mutant expressed in High Five cells using Bac to Bac insect cell expression system using tubulin as substrate by SDS-PAGE method B 5.86 pIC50 1380 nM IC50 J. Med. Chem. (2016) 59: 3793-3807 [PMID:27050625]
ChEMBL Inhibition of GRK2 (unknown origin) B 5.86 pIC50 1380 nM IC50 J Med Chem (2017) 60: 3052-3069 [PMID:28323425]
ChEMBL Inhibition of human GRK2 S670A mutant preincubated for 30 mins using tubulin as substrate followed by ATP addition B 5.96 pIC50 1100 nM IC50 J. Med. Chem. (2016) 59: 3793-3807 [PMID:27050625]
G protein-coupled receptor kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5678] [GtoPdb: 1469] [UniProtKB: P34947]
ChEMBL Inhibition of GRK5 (unknown origin) using tubulin as substrate by SDS-PAGE method B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2016) 59: 3793-3807 [PMID:27050625]
G protein-coupled receptor kinase 5 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879830] [UniProtKB: P43249]
ChEMBL Inhibition of bovine GRK5 after 5 mins after 5 mins in presence of ATP by phosphorimaging assay B 4 pIC50 >100000 nM IC50 J Med Chem (2017) 60: 3052-3069 [PMID:28323425]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) B 5.07 pKi 8544.5 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) B 4.98 pIC50 10429.3 nM IC50 DrugMatrix in vitro pharmacology data
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 7.46 pKi 35 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.84 pIC50 145 nM IC50 DrugMatrix in vitro pharmacology data
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.72 pKi 189 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.27 pIC50 532 nM IC50 DrugMatrix in vitro pharmacology data
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) B 7.42 pKi 38 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.75 pIC50 179 nM IC50 DrugMatrix in vitro pharmacology data
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) B 7.47 pKi 34 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.61 pIC50 244 nM IC50 DrugMatrix in vitro pharmacology data
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) B 7.05 pKi 89 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.91 pIC50 123 nM IC50 DrugMatrix in vitro pharmacology data
myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164]
ChEMBL Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed by H2O2 addition measured after 5 mins B 7.7 pIC50 20 nM IC50 J Med Chem (2017) 60: 6563-6586 [PMID:28671460]
NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
ChEMBL Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis B 6.05 pIC50 900 nM IC50 Bioorg. Med. Chem. (2013) 21: 2217-2228 [PMID:23477943]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporter B 7.4 pKd 40 nM Kd Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604]
ChEMBL Binding inhibition towards human norepinephrine transporter B 7.05 pKi 90 nM Ki J. Med. Chem. (2005) 48: 6023-6034 [PMID:16162005]
ChEMBL DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) B 7.07 pKi 86 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of norepinephrine uptake at human NET expressed in MDCK cells B 7 pIC50 100 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 4929-4931 [PMID:18771916]
ChEMBL DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) B 7.07 pIC50 86 nM IC50 DrugMatrix in vitro pharmacology data
NET/Norepinephrine transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2370] [GtoPdb: 926] [UniProtKB: O55192]
ChEMBL Tested in vitro for norepinephrine (NE) neuronal uptake inhibition B 7.7 pKi 20 nM Ki J. Med. Chem. (1990) 33: 2793-2797 [PMID:2213832]
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
ChEMBL Binding affinity against norepinephrine transporter (NET) by displacement of [3H]nisoxetine in male wistar rats B 6.18 pKi 659.6 nM Ki J. Med. Chem. (2003) 46: 5512-5532 [PMID:14640559]
ChEMBL Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomes B 7.48 pKi 33 nM Ki Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604]
ChEMBL Inhibition of [3H]nisoxetine (0.5 nM) binding to Noradrenaline transporter B 6.27 pIC50 535 nM IC50 J. Med. Chem. (1998) 41: 247-257 [PMID:9457247]
P2X4/P2X purinoceptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2104] [GtoPdb: 481] [UniProtKB: Q99571]
ChEMBL Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay B 5.33 pIC50 4680 nM IC50 Bioorg. Med. Chem. (2014) 22: 1077-1088 [PMID:24411477]
ChEMBL Antagonist activity at human P2X4 receptor expressed in 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx compound preincubated for 30 mins before ATP treatment by Fluo-4 AM fluorescence method F 5.73 pIC50 1870 nM IC50 J. Med. Chem. (2012) 55: 9576-9588 [PMID:23075067]
ChEMBL Antagonist activity at human P2X4 receptor tranfected in human 1321N1 cells assessed as inhibition of ATP-induced calcium influx incubated for 10 mins by Fluo2-AM staining based inverted fluorescence microscopic method B 5.73 pIC50 1870 nM IC50 J Med Chem (2019) 62: 11194-11217 [PMID:31746599]
GtoPdb - - 6 pIC50 - - - Mol Pharmacol (2013) 83: 759-69 [PMID:23253448];
Neuropharmacology (2016) 104: 31-49 [PMID:26686393]
P2X4/P2X purinoceptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2818] [GtoPdb: 481] [UniProtKB: P51577]
ChEMBL Antagonist activity at rat P2X4 receptor by cell-based calcium influx assay F 5.61 pIC50 2450 nM IC50 J. Med. Chem. (2012) 55: 9576-9588 [PMID:23075067]
ChEMBL Antagonist activity at rat P2X4 receptor tranfected in human 1321N1 cells assessed as inhibition of ATP-induced calcium influx incubated for 10 mins by Fluo2-AM staining based inverted fluorescence microscopic method B 5.61 pIC50 2450 nM IC50 J Med Chem (2019) 62: 11194-11217 [PMID:31746599]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL TP_TRANSPORTER: cell accumulation of calcein in L-MDR1 cells F 4.53 pIC50 29800 nM IC50 J. Pharmacol. Exp. Ther. (2003) 305: 197-204 [PMID:12649369]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL DNDI: Malaria in Vitro, 72 hour F 5.03 pIC50 9230 nM IC50 Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
Quinolone resistance protein norA in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5114] [UniProtKB: P0A0J7]
ChEMBL Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux dose response curve based fluorometric assay B 5.15 pIC50 7000 nM IC50 J. Med. Chem. (2011) 54: 5722-5736 [PMID:21751791]
G protein-coupled receptor kinase 1/Rhodopsin kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5607] [GtoPdb: 1465] [UniProtKB: Q15835]
ChEMBL Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE method B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2016) 59: 3793-3807 [PMID:27050625]
Rhodopsin kinase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879860] [UniProtKB: P28327]
ChEMBL Inhibition of bovine GRK1 (1 to 535 residues) after 5 mins after 5 mins in presence of ATP by phosphorimaging assay B 4 pIC50 >100000 nM IC50 J Med Chem (2017) 60: 3052-3069 [PMID:28323425]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity to 5HT1A receptor B 4.5 pKd 31622.78 nM Kd J. Med. Chem. (2009) 52: 6107-6125 [PMID:19754201]
ChEMBL Binding affinity to 5HT1A receptor B 4.52 pKd 30000 nM Kd J. Med. Chem. (2009) 52: 6107-6125 [PMID:19754201]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]8-OH-DPAT from rat hippocampus membranes B 6 pIC50 >1000 nM IC50 J. Med. Chem. (2003) 46: 5512-5532 [PMID:14640559]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranes B 6 pIC50 >1000 nM IC50 J. Med. Chem. (2003) 46: 5512-5532 [PMID:14640559]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERT B 9.89 pKd 0.13 nM Kd Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604]
GtoPdb - - 10.1 pKd 0.08 nM Kd Nature (2016) 532: 334-9 [PMID:27049939]
ChEMBL Displacement of [3H]citalopram from human SERT expressed in HEK293 cells B 9.38 pKi 0.42 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 4727-4730 [PMID:18644726]
ChEMBL Displacement of [3H]citalopram from human SERT expressed in HEK293 cells B 9.38 pKi 0.42 nM Ki Bioorg. Med. Chem. (2008) 16: 6364-6370 [PMID:18487050]
ChEMBL Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells B 9.42 pKi 0.38 nM Ki Bioorg. Med. Chem. (2008) 16: 6364-6370 [PMID:18487050]
ChEMBL Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells B 9.42 pKi 0.38 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 4727-4730 [PMID:18644726]
GtoPdb - - 9.6 pKi 0.25 nM Ki Eur J Pharmacol (1997) 340: 249-58 [PMID:9537821]
ChEMBL Displacement of [3H]citalopram from human SERT expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting method B 9.96 pKi 0.11 nM Ki Bioorg Med Chem (2017) 25: 293-304 [PMID:27865645]
ChEMBL Displacement of [3H]paroxetine from SERT receptor in human platelet membrane B 10.05 pKi 0.09 nM Ki Bioorg. Med. Chem. (2007) 15: 7581-7589 [PMID:17900912]
ChEMBL Evaluated for affinity at 5-HT uptake site using [3H]paroxetine as radioligand in radioligand binding assay B 10.11 pKi 0.08 nM Ki Bioorg. Med. Chem. Lett. (1995) 5: 2287-2292
ChEMBL DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) B 10.37 pKi 0.04 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL Binding inhibition towards human serotonin transporter B 10.4 pKi 0.04 nM Ki J. Med. Chem. (2005) 48: 6023-6034 [PMID:16162005]
ChEMBL Inhibition of human SERT B 7.7 pIC50 20 nM IC50 MedChemComm (2016) 7: 1176-1182
ChEMBL Inhibition of serotonin uptake at human SERT expressed in JAR cells B 8.7 pIC50 2 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 4929-4931 [PMID:18771916]
ChEMBL Inhibition of human SERT expressed in CHO cell membranes assessed as reduction in [3H]serotonin uptake preincubated for 10 mins followed by [3H]serotonin addition measured after 20 mins by liquid scintillation counting method B 9.25 pIC50 0.56 nM IC50 Bioorg Med Chem (2017) 25: 293-304 [PMID:27865645]
ChEMBL Displacement of [125I]RTI-55 from human recombinant SERT expressed in HEK293 cells after 1 hr by scintillation counting analysis B 9.7 pIC50 0.2 nM IC50 Bioorg. Med. Chem. (2013) 21: 2217-2228 [PMID:23477943]
ChEMBL DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) B 10.1 pIC50 0.08 nM IC50 DrugMatrix in vitro pharmacology data
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL The potency of the [3H]paroxetine for 5-HT transporters B 9.82 pKd 0.15 nM Kd J.