ChEMBL ligand: CHEMBL2403108 (Ceritinib, LDK378, NVP-LDK378-NX, Zykadia, LDK-378, NVP-LDK-378-NX)
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] There should be some charts here, you may need to enable JavaScript!
Insulin receptor in Human [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] There should be some charts here, you may need to enable JavaScript!
MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9] There should be some charts here, you may need to enable JavaScript!
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] There should be some charts here, you may need to enable JavaScript!
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] There should be some charts here, you may need to enable JavaScript!
c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922] There should be some charts here, you may need to enable JavaScript!
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] There should be some charts here, you may need to enable JavaScript!
p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177] There should be some charts here, you may need to enable JavaScript!
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] There should be some charts here, you may need to enable JavaScript!
testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7] There should be some charts here, you may need to enable JavaScript!
Transcription factor ETV6 in Human [ChEMBL: CHEMBL2401606] [UniProtKB: P41212] There should be some charts here, you may need to enable JavaScript!
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] There should be some charts here, you may need to enable JavaScript!
FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769] There should be some charts here, you may need to enable JavaScript!
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] There should be some charts here, you may need to enable JavaScript!
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] There should be some charts here, you may need to enable JavaScript!
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] There should be some charts here, you may need to enable JavaScript!
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] There should be some charts here, you may need to enable JavaScript!
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] There should be some charts here, you may need to enable JavaScript!
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL	Binding affinity to wild-type human partial length ALK (I1088 to E1409 residues) expressed in mammalian expression system by KINOMEscan assay	B	8.89	pKd	1.3	nM	Kd	Eur J Med Chem (2018) 151: 304-314 [PMID:29627725]
ChEMBL	Inhibition of human N-terminal GST-tagged ALK G1202R mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system after 1 hr by mobility shift assay	B	4.04	pIC50	91000	nM	IC50	Eur J Med Chem (2018) 158: 322-333 [PMID:30223120]
ChEMBL	Inhibition of human N-terminal GST-tagged ALK L1196M mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system after 1 hr by mobility shift assay	B	4.46	pIC50	35000	nM	IC50	Eur J Med Chem (2018) 158: 322-333 [PMID:30223120]
ChEMBL	Inhibition of human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system after 1 hr by mobility shift assay	B	5.54	pIC50	2900	nM	IC50	Eur J Med Chem (2018) 158: 322-333 [PMID:30223120]
ChEMBL	Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) G1202R mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay	B	7.04	pIC50	91	nM	IC50	Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL	Inhibition of ALK L1196M mutant (unknown origin) using peptide as substrate after 60 mins by HTRF assay	B	7.19	pIC50	64	nM	IC50	Eur J Med Chem (2016) 123: 80-89 [PMID:27474925]
ChEMBL	Inhibition of TEL-fused ALK (unknown origin) by cell-based assay	B	7.39	pIC50	40.7	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL	Inhibition of ALK (unknown origin) transfected in mouse BA/F3 cells	B	7.39	pIC50	40.7	nM	IC50	J. Med. Chem. (2013) 56: 5673-5674 [PMID:23837797]
ChEMBL	Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) L1196M mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay	B	7.46	pIC50	35	nM	IC50	Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL	Inhibition of ALK L1196M mutant (unknown origin) by homogeneous time resolved fluorescence assay	B	7.54	pIC50	29	nM	IC50	Bioorg. Med. Chem. Lett. (2015) 25: 3992-3998 [PMID:26235945]
ChEMBL	Inhibition of ALK L1196M mutant (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay	B	7.54	pIC50	29	nM	IC50	Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL	Inhibition of ALK L1196M mutant (unknown origin) using TK as substrate after 30 mins by HTRF assay	B	7.54	pIC50	29	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2185-2191 [PMID:28385505]
ChEMBL	Inhibition of ALK L1196M mutant (unknown origin) after 30 mins by HTRF assay	B	7.54	pIC50	29	nM	IC50	Bioorg. Med. Chem. Lett. (2016) 26: 1720-1725 [PMID:26923695]
ChEMBL	Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay	B	7.59	pIC50	26	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL	Inhibition of wild type ALK (unknown origin) using TK as substrate after 30 mins by HTRF assay	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2185-2191 [PMID:28385505]
ChEMBL	Inhibition of wild type ALK (unknown origin) after 30 mins by HTRF assay	B	7.85	pIC50	14	nM	IC50	Bioorg. Med. Chem. Lett. (2016) 26: 1720-1725 [PMID:26923695]
ChEMBL	Inhibition of wild-type ALK (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay	B	7.85	pIC50	14	nM	IC50	Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL	Inhibition of wild type ALK (unknown origin) by homogeneous time resolved fluorescence assay	B	7.85	pIC50	14	nM	IC50	Bioorg. Med. Chem. Lett. (2015) 25: 3992-3998 [PMID:26235945]
ChEMBL	Inhibition of ALK G1202R mutant (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL	Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) S1206Y mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay	B	8.34	pIC50	4.6	nM	IC50	Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL	Inhibition of purified ALK (unknown origin) after 60 mins by ELISA kinase assay	B	8.47	pIC50	3.4	nM	IC50	Eur. J. Med. Chem. (2014) 86: 438-448 [PMID:25200979]
ChEMBL	Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISA	B	8.47	pIC50	3.4	nM	IC50	Eur J Med Chem (2018) 144: 386-397 [PMID:29288940]
ChEMBL	Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) G1269A mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay	B	8.47	pIC50	3.4	nM	IC50	Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL	Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) C1156Y mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay	B	8.54	pIC50	2.9	nM	IC50	Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL	Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay	B	8.54	pIC50	2.9	nM	IC50	Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL	Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) T1151 insertion mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay	B	8.6	pIC50	2.5	nM	IC50	Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL	Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay	B	8.64	pIC50	2.3	nM	IC50	Eur J Med Chem (2016) 123: 80-89 [PMID:27474925]
ChEMBL	Inhibition of EML4-fused ALK (unknown origin) by cell-based assay	B	8.66	pIC50	2.2	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL	Inhibition of ALK C1156Y mutant (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay	B	8.7	pIC50	2	nM	IC50	Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL	Inhibition of ALK F1174L mutant (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay	B	8.82	pIC50	1.5	nM	IC50	Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL	Inhibition of ALK G1269A mutant (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay	B	8.85	pIC50	1.4	nM	IC50	Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL	Inhibition of ALK (unknown origin) after 60 mins	B	9.7	pIC50	0.2	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL	Inhibition of ALK (unknown origin)	B	9.7	pIC50	0.2	nM	IC50	J. Med. Chem. (2013) 56: 5673-5674 [PMID:23837797]
GtoPdb	-	-	9.7	pIC50	0.2	nM	IC50	J. Med. Chem. (2013) 56: 5675-90 [PMID:23742252]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of CDK2 (unknown origin) after 60 mins	B	5.4	pIC50	3970	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
ChEMBL	Inhibition of CDK4 (unknown origin) after 60 mins	B	5.33	pIC50	4720	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay	B	6	pIC50	>1000	nM	IC50	Eur J Med Chem (2016) 123: 80-89 [PMID:27474925]
ChEMBL	Inhibition of recombinant human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay	B	6	pIC50	>1000	nM	IC50	Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL	Inhibition of EGFR (unknown origin) after 60 mins	B	6.05	pIC50	900	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
ChEMBL	Inhibition of FGFR2 (unknown origin) after 60 mins	B	6.59	pIC50	260	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
ChEMBL	Inhibition of TEL-fused FGFR3 (unknown origin) by cell-based assay	B	5	pIC50	>10000	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL	Inhibition of FGFR3 (unknown origin) after 60 mins	B	6.37	pIC50	430	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
ChEMBL	Inhibition of FGFR4 (unknown origin) after 60 mins	B	6.02	pIC50	950	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of GSK3beta (unknown origin) after 60 mins	B	5	pIC50	>10000	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL	Inhibition of cMET (unknown origin) after 60 mins	B	5.5	pIC50	3170	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL	Inhibition of TEL-fused MET (unknown origin) by cell-based assay	B	5.87	pIC50	1339	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL	Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay	B	6	pIC50	>1000	nM	IC50	Eur J Med Chem (2016) 123: 80-89 [PMID:27474925]
ChEMBL	Inhibition of recombinant human N-terminal GST-tagged c-MET cytoplasmic domain (956 to 1390 residues) expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay	B	6	pIC50	>1000	nM	IC50	Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG by patch-clamp technique	B	4.34	pIC50	46000	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL	Inhibition of human ERG by patch clamp method	B	4.34	pIC50	46000	nM	IC50	J. Med. Chem. (2013) 56: 5673-5674 [PMID:23837797]
ChEMBL	Inhibition of human ERG by dofetilide binding assay	B	5.9	pIC50	1250	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL	Inhibition of TEL-fused IGF1 receptor (unknown origin) by cell-based assay	B	6.39	pIC50	410	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL	Inhibition of IGF1 receptor (unknown origin) after 60 mins	B	8.1	pIC50	8	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
GtoPdb	-	-	8.1	pIC50	8	nM	IC50	J. Med. Chem. (2013) 56: 5675-90 [PMID:23742252]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL	Inhibition of TEL-fused insulin receptor (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay	B	6.5	pIC50	319.5	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL	Inhibition of insulin receptor (unknown origin) by homogeneous time resolved fluorescence assay	B	7.03	pIC50	93	nM	IC50	Bioorg. Med. Chem. Lett. (2015) 25: 3992-3998 [PMID:26235945]
ChEMBL	Inhibition of insulin receptor kinase (unknown origin) using TK as substrate after 30 mins by HTRF assay	B	7.62	pIC50	24	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2185-2191 [PMID:28385505]
GtoPdb	-	-	8.15	pIC50	7	nM	IC50	J. Med. Chem. (2013) 56: 5675-90 [PMID:23742252]
ChEMBL	Inhibition of insulin receptor (unknown origin) after 60 mins	B	8.15	pIC50	7	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
ChEMBL	Inhibition of MKNK2 (unknown origin) after 60 mins	B	5.65	pIC50	2240	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
ChEMBL	Inhibition of TEL-fused TRKA (unknown origin) by cell-based assay	B	5.56	pIC50	2727	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
ChEMBL	Inhibition of TEL-fused TRKB (unknown origin) by cell-based assay	B	5.74	pIC50	1829	nM	IC50	J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL	Inhibition of PDGFRalpha (unknown origin) after 60 mins	B