ceritinib [Ligand Id: 7397] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2403108 (Ceritinib, LDK378, NVP-LDK378-NX, Zykadia, LDK-378, NVP-LDK-378-NX)
  • ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
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  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
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  • cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
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  • fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
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  • fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
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  • Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
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  • MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
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  • neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
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  • neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
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  • platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
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  • c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922]
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  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
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  • p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177]
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  • KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
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  • testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7]
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  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
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  • Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
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  • FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769]
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  • Janus kinase 1/Tyrosine-protein kinase JAK1 in Human [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
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  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
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  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
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  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
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  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
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  • fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
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  • ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
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  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
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  • spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
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  • zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
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  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL Binding affinity to wild-type human partial length ALK (I1088 to E1409 residues) expressed in mammalian expression system by KINOMEscan assay B 8.89 pKd 1.3 nM Kd Eur J Med Chem (2018) 151: 304-314 [PMID:29627725]
ChEMBL Inhibition of human N-terminal GST-tagged ALK G1202R mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system after 1 hr by mobility shift assay B 4.04 pIC50 91000 nM IC50 Eur J Med Chem (2018) 158: 322-333 [PMID:30223120]
ChEMBL Inhibition of human N-terminal GST-tagged ALK L1196M mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system after 1 hr by mobility shift assay B 4.46 pIC50 35000 nM IC50 Eur J Med Chem (2018) 158: 322-333 [PMID:30223120]
ChEMBL Inhibition of human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system after 1 hr by mobility shift assay B 5.54 pIC50 2900 nM IC50 Eur J Med Chem (2018) 158: 322-333 [PMID:30223120]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) G1202R mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay B 7.04 pIC50 91 nM IC50 Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL Inhibition of ALK L1196M mutant (unknown origin) using peptide as substrate after 60 mins by HTRF assay B 7.19 pIC50 64 nM IC50 Eur J Med Chem (2016) 123: 80-89 [PMID:27474925]
ChEMBL Inhibition of TEL-fused ALK (unknown origin) by cell-based assay B 7.39 pIC50 40.7 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL Inhibition of ALK (unknown origin) transfected in mouse BA/F3 cells B 7.39 pIC50 40.7 nM IC50 J. Med. Chem. (2013) 56: 5673-5674 [PMID:23837797]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) L1196M mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay B 7.46 pIC50 35 nM IC50 Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL Inhibition of ALK L1196M mutant (unknown origin) by homogeneous time resolved fluorescence assay B 7.54 pIC50 29 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 3992-3998 [PMID:26235945]
ChEMBL Inhibition of ALK L1196M mutant (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay B 7.54 pIC50 29 nM IC50 Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL Inhibition of ALK L1196M mutant (unknown origin) using TK as substrate after 30 mins by HTRF assay B 7.54 pIC50 29 nM IC50 Bioorg Med Chem Lett (2017) 27: 2185-2191 [PMID:28385505]
ChEMBL Inhibition of ALK L1196M mutant (unknown origin) after 30 mins by HTRF assay B 7.54 pIC50 29 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 1720-1725 [PMID:26923695]
ChEMBL Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay B 7.59 pIC50 26 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL Inhibition of wild type ALK (unknown origin) using TK as substrate after 30 mins by HTRF assay B 7.85 pIC50 14 nM IC50 Bioorg Med Chem Lett (2017) 27: 2185-2191 [PMID:28385505]
ChEMBL Inhibition of wild type ALK (unknown origin) after 30 mins by HTRF assay B 7.85 pIC50 14 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 1720-1725 [PMID:26923695]
ChEMBL Inhibition of wild-type ALK (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay B 7.85 pIC50 14 nM IC50 Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL Inhibition of wild type ALK (unknown origin) by homogeneous time resolved fluorescence assay B 7.85 pIC50 14 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 3992-3998 [PMID:26235945]
ChEMBL Inhibition of ALK G1202R mutant (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay B 7.89 pIC50 13 nM IC50 Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) S1206Y mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay B 8.34 pIC50 4.6 nM IC50 Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL Inhibition of purified ALK (unknown origin) after 60 mins by ELISA kinase assay B 8.47 pIC50 3.4 nM IC50 Eur. J. Med. Chem. (2014) 86: 438-448 [PMID:25200979]
ChEMBL Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISA B 8.47 pIC50 3.4 nM IC50 Eur J Med Chem (2018) 144: 386-397 [PMID:29288940]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) G1269A mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay B 8.47 pIC50 3.4 nM IC50 Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) C1156Y mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay B 8.54 pIC50 2.9 nM IC50 Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay B 8.54 pIC50 2.9 nM IC50 Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) T1151 insertion mutant expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay B 8.6 pIC50 2.5 nM IC50 Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay B 8.64 pIC50 2.3 nM IC50 Eur J Med Chem (2016) 123: 80-89 [PMID:27474925]
ChEMBL Inhibition of EML4-fused ALK (unknown origin) by cell-based assay B 8.66 pIC50 2.2 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL Inhibition of ALK C1156Y mutant (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay B 8.7 pIC50 2 nM IC50 Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL Inhibition of ALK F1174L mutant (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay B 8.82 pIC50 1.5 nM IC50 Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL Inhibition of ALK G1269A mutant (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assay B 8.85 pIC50 1.4 nM IC50 Eur J Med Chem (2017) 126: 536-549 [PMID:27915169]
ChEMBL Inhibition of ALK (unknown origin) after 60 mins B 9.7 pIC50 0.2 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL Inhibition of ALK (unknown origin) B 9.7 pIC50 0.2 nM IC50 J. Med. Chem. (2013) 56: 5673-5674 [PMID:23837797]
GtoPdb - - 9.7 pIC50 0.2 nM IC50 J. Med. Chem. (2013) 56: 5675-90 [PMID:23742252]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Inhibition of CDK2 (unknown origin) after 60 mins B 5.4 pIC50 3970 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
ChEMBL Inhibition of CDK4 (unknown origin) after 60 mins B 5.33 pIC50 4720 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay B 6 pIC50 >1000 nM IC50 Eur J Med Chem (2016) 123: 80-89 [PMID:27474925]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay B 6 pIC50 >1000 nM IC50 Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
ChEMBL Inhibition of EGFR (unknown origin) after 60 mins B 6.05 pIC50 900 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
ChEMBL Inhibition of FGFR2 (unknown origin) after 60 mins B 6.59 pIC50 260 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
ChEMBL Inhibition of TEL-fused FGFR3 (unknown origin) by cell-based assay B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL Inhibition of FGFR3 (unknown origin) after 60 mins B 6.37 pIC50 430 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
ChEMBL Inhibition of FGFR4 (unknown origin) after 60 mins B 6.02 pIC50 950 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of GSK3beta (unknown origin) after 60 mins B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL Inhibition of cMET (unknown origin) after 60 mins B 5.5 pIC50 3170 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL Inhibition of TEL-fused MET (unknown origin) by cell-based assay B 5.87 pIC50 1339 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay B 6 pIC50 >1000 nM IC50 Eur J Med Chem (2016) 123: 80-89 [PMID:27474925]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged c-MET cytoplasmic domain (956 to 1390 residues) expressed in baculovirus expression system using peptide substrate after 1 hr by mobility shift assay B 6 pIC50 >1000 nM IC50 Eur J Med Chem (2018) 143: 123-136 [PMID:29174809]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG by patch-clamp technique B 4.34 pIC50 46000 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL Inhibition of human ERG by patch clamp method B 4.34 pIC50 46000 nM IC50 J. Med. Chem. (2013) 56: 5673-5674 [PMID:23837797]
ChEMBL Inhibition of human ERG by dofetilide binding assay B 5.9 pIC50 1250 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL Inhibition of TEL-fused IGF1 receptor (unknown origin) by cell-based assay B 6.39 pIC50 410 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL Inhibition of IGF1 receptor (unknown origin) after 60 mins B 8.1 pIC50 8 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
GtoPdb - - 8.1 pIC50 8 nM IC50 J. Med. Chem. (2013) 56: 5675-90 [PMID:23742252]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL Inhibition of TEL-fused insulin receptor (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay B 6.5 pIC50 319.5 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
ChEMBL Inhibition of insulin receptor (unknown origin) by homogeneous time resolved fluorescence assay B 7.03 pIC50 93 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 3992-3998 [PMID:26235945]
ChEMBL Inhibition of insulin receptor kinase (unknown origin) using TK as substrate after 30 mins by HTRF assay B 7.62 pIC50 24 nM IC50 Bioorg Med Chem Lett (2017) 27: 2185-2191 [PMID:28385505]
GtoPdb - - 8.15 pIC50 7 nM IC50 J. Med. Chem. (2013) 56: 5675-90 [PMID:23742252]
ChEMBL Inhibition of insulin receptor (unknown origin) after 60 mins B 8.15 pIC50 7 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
ChEMBL Inhibition of MKNK2 (unknown origin) after 60 mins B 5.65 pIC50 2240 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
ChEMBL Inhibition of TEL-fused TRKA (unknown origin) by cell-based assay B 5.56 pIC50 2727 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
ChEMBL Inhibition of TEL-fused TRKB (unknown origin) by cell-based assay B 5.74 pIC50 1829 nM IC50 J. Med. Chem. (2013) 56: 5675-5690 [PMID:23742252]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL Inhibition of PDGFRalpha (unknown origin) after 60 mins B