compound 12c [PMID: 16516466] [Ligand Id: 8663] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL208009 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| ChEMBL | Inhibition of LPS-stimulated TNFalpha production in human whole blood | F | 7.44 | pIC50 | 36 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| ADAM17 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3332] [UniProtKB: O77636] | ||||||||
| ChEMBL | Inhibition of porcine TACE | B | 8.72 | pIC50 | 1.9 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| ADAMTS1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5133] [GtoPdb: 1674] [UniProtKB: Q9UHI8] | ||||||||
| GtoPdb | - | - | 6.11 | pKi | 776 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-704 [PMID:16516466] |
| ChEMBL | Binding affinity to ADAMTS1 | B | 6.11 | pKi | 776 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| ADAMTS4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2318] [GtoPdb: 1677] [UniProtKB: O75173] | ||||||||
| ChEMBL | Binding affinity to ADAMTS4 | B | 5.74 | pKi | 1834 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| ADAMTS5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2285] [GtoPdb: 1678] [UniProtKB: Q9UNA0] | ||||||||
| ChEMBL | Binding affinity to ADAMTS5 | B | 7.01 | pKi | 97 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Binding affinity to MMP1 | B | 5.31 | pKi | >4949 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Binding affinity to MMP13 | B | 5.3 | pKi | >5025 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Binding affinity to MMP14 | B | 5.28 | pKi | >5290 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP15/Matrix metalloproteinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2963] [GtoPdb: 1639] [UniProtKB: P51511] | ||||||||
| ChEMBL | Binding affinity to MMP15 | B | 5.15 | pKi | >7088 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP16/Matrix metalloproteinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512] | ||||||||
| ChEMBL | Binding affinity to MMP16 | B | 5.26 | pKi | >5554 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Binding affinity to MMP2 | B | 5.48 | pKi | >3333 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Binding affinity to MMP3 | B | 7.04 | pKi | 91 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Binding affinity to MMP7 | B | 7.74 | pKi | 18 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Binding affinity to MMP8 | B | 6.66 | pKi | 217 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Binding affinity to MMP9 | B | 5.67 | pKi | >2128 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
