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ChEMBL ligand: CHEMBL294192 (NE11808) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 7.43 | pKi | 36.9 | nM | Ki | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | B | 7.43 | pKi | 36.9 | nM | Ki | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
ChEMBL | Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand | B | 7.8 | pKi | 16 | nM | Ki | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | B | 8.64 | pKi | 2.3 | nM | Ki | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 8.64 | pKi | 2.3 | nM | Ki | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 6.72 | pIC50 | 190.1 | nM | IC50 | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | B | 6.72 | pIC50 | 190.1 | nM | IC50 | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase was determined | B | 6.77 | pIC50 | 170 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) | B | 6.77 | pIC50 | 169.82 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7] | ||||||||
ChEMBL | Inhibitory activity against Leishmania major Farnesyl diphosphate synthase | B | 6.77 | pIC50 | 170 | nM | IC50 | J Med Chem (2004) 47: 175-187 [PMID:14695831] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Growth inhibition of Plasmodium falciparum | F | 4.55 | pIC50 | 28000 | nM | IC50 | J Med Chem (2008) 51: 7827-7833 [PMID:19053772] |
ChEMBL | Growth inhibition of Plasmodium falciparum | F | 4.6 | pIC50 | 25118.86 | nM | IC50 | J Med Chem (2008) 51: 7827-7833 [PMID:19053772] |
ChEMBL | In vitro growth inhibition against Plasmodium falciparum | F | 4.77 | pIC50 | 17000 | nM | IC50 | J Med Chem (2004) 47: 175-187 [PMID:14695831] |
ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.77 | pIC50 | 17000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]