brodimoprim [Ligand Id: 12325] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL31891 (Brodimoprim, Brodimoprima, Brodimoprime) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dihydrofolate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1809] [UniProtKB: P0ABQ4] | ||||||||
| ChEMBL | Inhibition constant against binding of Escherichia coli dihydrofolate reductase | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1988) 31: 1396-1406 [PMID:3290487] |
| ChEMBL | Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase. | B | 8.53 | pIC50 | 2.95 | nM | IC50 | J Med Chem (1996) 39: 4825-4832 [PMID:8941396] |
| Dihydrofolate reductase in Lactobacillus casei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2902] [UniProtKB: P00381] | ||||||||
| ChEMBL | Inhibitory activity against Lactobacillus casei dihydrofolate reductase | B | 7.28 | pKi | 52.48 | nM | Ki | J Med Chem (1989) 32: 1895-1905 [PMID:2502631] |
| ChEMBL | Inhibition constant of compound against Lactobacillus casei dihydrofolate reductase | B | 7.95 | pKi | 11.3 | nM | Ki | J Med Chem (1984) 27: 1672-1676 [PMID:6438320] |
| Dihydrofolate reductase in Pneumocystis carinii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926] [UniProtKB: P16184] | ||||||||
| ChEMBL | Inhibition of Pneumocystis carinii Dihydrofolate Reductase | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1997) 40: 3694-3699 [PMID:9357537] |
| Dihydrofolate reductase in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2425] [UniProtKB: Q07422] | ||||||||
| ChEMBL | Inhibition of Toxoplasma gondii Dihydrofolate Reductase | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1997) 40: 3694-3699 [PMID:9357537] |
| Dihydrofolate reductase in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2575] [UniProtKB: P00378] | ||||||||
| ChEMBL | Inhibitory activity against chicken liver dihydrofolate reductase | B | 4.54 | pKi | 28840.32 | nM | Ki | J Med Chem (1989) 32: 1895-1905 [PMID:2502631] |
| dihydrofolate reductase/Dihydrofolate reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2363] [GtoPdb: 2603] [UniProtKB: Q920D2] | ||||||||
| ChEMBL | Inhibition of rat liver Dihydrofolate Reductase | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1997) 40: 3694-3699 [PMID:9357537] |
| Dihydrofolate reductase in Salmonella enterica subsp. enterica serovar Typhi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4888] [UniProtKB: Q8Z9J9] | ||||||||
| ChEMBL | Inhibitory activity against Escherichia coli dihydrofolate reductase | B | 8.18 | pKi | 6.61 | nM | Ki | J Med Chem (1991) 34: 46-54 [PMID:1899453] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
