risedronate [Ligand Id: 3176] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL923 (Risedronate, Actonel, M05BA07, Risedronic Acid, NE-58095)
  • Farnesyl diphosphate synthase in Trypanosoma cruzi [ChEMBL: CHEMBL4752] [UniProtKB: Q8WS26]
  • Farnesyl diphosphate synthase in Toxoplasma gondii [ChEMBL: CHEMBL5831] [UniProtKB: Q197X6]
  • farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
1 CHEMBL923_lig_chart_1 Farnesyl diphosphate synthase Trypanosoma cruziToxoplasma gondiiHuman
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  • Farnesyl pyrophosphate synthase in Leishmania donovani [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
  • This target only has 1 pki data point
2 CHEMBL923_lig_chart_2 Farnesyl pyrophosphate synthase Leishmania donovani
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  • geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
  • This target only has 0 pki data point
3 CHEMBL923_lig_chart_3 Geranylgeranyl pyrophosphate synthetase Human
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  • Plasmodium berghei [ChEMBL: CHEMBL612653]
  • This target only has 0 pki data point
4 CHEMBL923_lig_chart_4 Plasmodium berghei Plasmodium berghei
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
5 CHEMBL923_lig_chart_5 Plasmodium falciparum Plasmodium falciparum
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Farnesyl diphosphate synthase in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4752] [UniProtKB: Q8WS26]
ChEMBL Inhibition of Trypanosoma cruzi FPPS after 30 mins using [14C]IPP by scintillation counting B 7.57 pIC50 27 nM IC50 Bioorg. Med. Chem. (2011) 19: 2211-2217 [PMID:21419634]
ChEMBL Inhibition of Trypanosoma cruzi farnesyl diphosphate synthase assessed as incorporation of [4-14C]IPP measured at 37 degC B 7.57 pIC50 27 nM IC50 Eur. J. Med. Chem. (2013) 60: 431-440 [PMID:23318904]
Farnesyl diphosphate synthase in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5831] [UniProtKB: Q197X6]
ChEMBL Inhibition of Toxoplasma gondii FPPS after 30 mins using [14C]IPP by scintillation counting B 7.13 pIC50 74 nM IC50 Bioorg. Med. Chem. (2011) 19: 2211-2217 [PMID:21419634]
ChEMBL Inhibition of Toxoplasma gondii farnesyl diphosphate synthase assessed as incorporation of [4-14C]IPP measured at 37 degC B 7.13 pIC50 74 nM IC50 Eur. J. Med. Chem. (2013) 60: 431-440 [PMID:23318904]
ChEMBL Inhibition of Toxoplasma gondii recombinant FPPS expressed in Escherichia coli using [4-14C]IPP/DMAPP/GPP as substrate after 30 mins by scintillation counting analysis B 7.13 pIC50 74 nM IC50 Bioorg. Med. Chem. (2014) 22: 398-405 [PMID:24300918]
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 B 7.09 pKi 82.2 nM Ki J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins - 7.09 pKi 82.2 nM Ki J. Med. Chem. (2008) 51: 2187-95 [PMID:18327899]
ChEMBL Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand B 7.8 pKi 16 nM Ki J. Med. Chem. (2003) 46: 5171-5183 [PMID:14613320]
GtoPdb Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins - 9.44 pKi 0.36 nM Ki J. Med. Chem. (2008) 51: 2187-95 [PMID:18327899]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins B 9.44 pKi 0.36 nM Ki J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate measured after 20 mins by liquid scintillation counting B 6.07 pIC50 860 nM IC50 J. Med. Chem. (2012) 55: 3201-3215 [PMID:22390415]
GtoPdb Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins - 6.34 pIC50 452.9 nM IC50 J. Med. Chem. (2008) 51: 2187-95 [PMID:18327899]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 B 6.34 pIC50 452.9 nM IC50 J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL Inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli B 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 5781-5786 [PMID:20801032]
ChEMBL Inhibitory activity against farnesyl Pyrophosphate Synthase was determined B 6.77 pIC50 170 nM IC50 J. Med. Chem. (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) B 6.77 pIC50 169.82 nM IC50 J. Med. Chem. (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL Inhibition of human FPPS in absence of pre-incubation of compound with enzyme B 7.09 pIC50 82 nM IC50 ACS Med. Chem. Lett. (2015) 6: 349-354 [PMID:25815158]
ChEMBL Inhibition of recombinant human C-terminal His6-tagged FPPS expressed in Escherichia coli BL21 using DMAPP and IPP as substrates pretreated for 15 mins followed by substrates addition and measured after 1 hr by colorimetric method B 7.15 pIC50 70 nM IC50 Eur J Med Chem (2018) 158: 184-200 [PMID:30216851]
ChEMBL Inhibition of human His6-tagged recombinant FPPS expressed in Escherichia coli BL21(DE3) using GPP and [3H]IPP as substrate incubated for 5 mins prior to substrate addition measured after 20 mins by liquid scintillation counting B 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. (2012) 20: 5583-5591 [PMID:22884353]
ChEMBL Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 mins prior to substrate addition measured after 10 mins by scintillation counting B 7.96 pIC50 11 nM IC50 J. Med. Chem. (2012) 55: 3201-3215 [PMID:22390415]
ChEMBL Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate incubated for 10 mins prior to substrate addition by scintillation counting analysis B 7.96 pIC50 11 nM IC50 J. Med. Chem. (2013) 56: 7939-7950 [PMID:23998921]
ChEMBL Inhibition of human FPPS B 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 1117-1123 [PMID:25630225]
GtoPdb In vitro inhibition of recombinant human FDPS expressed in E.coli. - 8 pIC50 10 nM IC50 J. Pharmacol. Exp. Ther. (2001) 296: 235-42 [PMID:11160603]
ChEMBL Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting B 8 pIC50 10 nM IC50 J. Med. Chem. (2011) 54: 5955-5980 [PMID:21780776]
ChEMBL Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzyme B 8 pIC50 10 nM IC50 J. Med. Chem. (2002) 45: 2185-2196 [PMID:12014956]
ChEMBL Inhibition of FDPS (unknown origin) B 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 2331-2334 [PMID:25935643]
ChEMBL Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by liquid scintillation counting analysis B 8.22 pIC50 6 nM IC50 J. Med. Chem. (2014) 57: 5764-5776 [PMID:24911527]
GtoPdb in vitro assay, inhibition of recombinant human enzyme expressed in E.coli - 8.24 pIC50 5.7 nM IC50 J. Pharmacol. Exp. Ther. (2001) 296: 235-42 [PMID:11160603]
GtoPdb Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins - 8.24 pIC50 5.7 nM IC50 J. Med. Chem. (2008) 51: 2187-95 [PMID:18327899]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins B 8.24 pIC50 5.7 nM IC50 J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL Inhibition of human FPPS B 8.24 pIC50 5.7 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 2878-2882 [PMID:18434151]
ChEMBL Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate incubated for 10 mins prior to substrate addition measured after 8 mins by scintillation counting analysis B 8.28 pIC50 5.2 nM IC50 J. Med. Chem. (2013) 56: 7939-7950 [PMID:23998921]
GtoPdb - - 8.41 pIC50 3.9 nM IC50 Arch. Biochem. Biophys. (2000) 373: 231-41 [PMID:10620343]
ChEMBL Inhibition of human FPPS using pre-incubation of compound with enzyme B 9.44 pIC50 0.36 nM IC50 ACS Med. Chem. Lett. (2015) 6: 349-354 [PMID:25815158]
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
ChEMBL Binding affinity towards Farnesyl diphosphate synthase from leishmania major B 7.77 pKi 17 nM Ki J. Med. Chem. (2005) 48: 2957-2963 [PMID:15828834]
ChEMBL Inhibitory activity against Leishmania major Farnesyl diphosphate synthase B 6.77 pIC50 170 nM IC50 J. Med. Chem. (2004) 47: 175-187 [PMID:14695831]
ChEMBL Inhibitory activity against FPPS in Leishmania major B 6.77 pIC50 170 nM IC50 J. Med. Chem. (2006) 49: 215-223 [PMID:16392806]
ChEMBL Inhibitory activity against FPPS in Leishmania major B 6.77 pIC50 169.82 nM IC50 J. Med. Chem. (2006) 49: 215-223 [PMID:16392806]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
ChEMBL Inhibition of human recombinant N-terminal His6 tagged GGPPS expressed in Escherichia coli BL21 using FPP and [14C]IPP as substrate incubated for 10 mins prior to substrate addition by scintillation counting B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2012) 55: 3201-3215 [PMID:22390415]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR F 4.8 pIC50 16000 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 2987-2993 [PMID:20457823]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2mef assessed as suppression of parasitemia by microscopic analysis F 5.85 pIC50 1400 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 2987-2993 [PMID:20457823]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as suppression of parasitemia by microscopic analysis F 5.92 pIC50 1200 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 2987-2993 [PMID:20457823]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]