3-keto-lithocholic acid [Ligand Id: 2766] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL410893
  • GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
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  • Vitamin D receptor in Human [GtoPdb: 605] [UniProtKB: P11473]
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  • Pregnane X receptor in Human [GtoPdb: 606] [UniProtKB: O75469]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL Agonist activity at human TGR5 expressed in CHO cells by luciferase assay F 6.57 pEC50 270 nM EC50 J Med Chem (2008) 51: 1831-1841 [PMID:18307294]
Vitamin D receptor in Human [GtoPdb: 605] [UniProtKB: P11473]
GtoPdb - - 6.54 pKi - - - Science (2002) 296: 1313-6 [PMID:12016314]
Pregnane X receptor in Human [GtoPdb: 606] [UniProtKB: O75469]
GtoPdb - - 4.8 pEC50 - - - Proc Natl Acad Sci USA (2001) 98: 3369-74 [PMID:11248085]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]