ChEMBL ligand: CHEMBL410893
GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] There should be some charts here, you may need to enable JavaScript!
Vitamin D receptor in Human [GtoPdb: 605] [UniProtKB: P11473] There should be some charts here, you may need to enable JavaScript!
Pregnane X receptor in Human [GtoPdb: 606] [UniProtKB: O75469] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL	Agonist activity at human TGR5 expressed in CHO cells by luciferase assay	F	6.57	pEC50	270	nM	EC50	J Med Chem (2008) 51: 1831-1841 [PMID:18307294]
Vitamin D receptor in Human [GtoPdb: 605] [UniProtKB: P11473]
GtoPdb	-	-	6.54	pKi	-	-	-	Science (2002) 296: 1313-6 [PMID:12016314]
Pregnane X receptor in Human [GtoPdb: 606] [UniProtKB: O75469]
GtoPdb	-	-	4.8	pEC50	-	-	-	Proc Natl Acad Sci USA (2001) 98: 3369-74 [PMID:11248085]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]