3-keto-lithocholic acid [Ligand Id: 2766] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL410893
  • GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
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  • Vitamin D receptor in Human [GtoPdb: 605] [UniProtKB: P11473]
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  • Pregnane X receptor in Human [GtoPdb: 606] [UniProtKB: O75469]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL Agonist activity at human TGR5 expressed in CHO cells by luciferase assay F 6.57 pEC50 270 nM EC50 J. Med. Chem. (2008) 51: 1831-1841 [PMID:18307294]
Vitamin D receptor in Human [GtoPdb: 605] [UniProtKB: P11473]
GtoPdb - - 6.54 pKi - - - Science (2002) 296: 1313-6 [PMID:12016314]
Pregnane X receptor in Human [GtoPdb: 606] [UniProtKB: O75469]
GtoPdb - - 4.8 pEC50 - - - Proc Natl Acad Sci USA (2001) 98: 3369-74 [PMID:11248085]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]