volinanserin [Ligand Id: 185] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL74355 (M-100907, M100907, Mdl-100907, MDL-100.907, MDL-100907, MDL100.907, Volinanserin, Volinanserina, Volinanserine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
| ChEMBL | PDSP Secondary Binding target: ADRA1B - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity. | B | 5.42 | pKi | 3807.59 | nM | Ki | EUbOPEN Chemogenomics Library - PDSP Secondary Binding |
| α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] | ||||||||
| ChEMBL | PDSP Secondary Binding target: ADRA2B - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity. | B | 5.89 | pKi | 1288.54 | nM | Ki | EUbOPEN Chemogenomics Library - PDSP Secondary Binding |
| D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| ChEMBL | PDSP Secondary Binding target: DRD1 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity. | B | 6.07 | pKi | 859.31 | nM | Ki | EUbOPEN Chemogenomics Library - PDSP Secondary Binding |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity to dopamine D2 receptor by competitive binding experiment | B | 5.65 | pKi | 2250 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| ChEMBL | Binding affinity for displacement of [3H]spiperone to human dopamine D2 (hD2) receptors stably expressed in CHO cells | B | 5.89 | pKi | 1300 | nM | Ki | J Med Chem (2002) 45: 492-503 [PMID:11784153] |
| ChEMBL | Ability to displace [3H]-spiperone from CHO cells expressing human Dopamine receptor D2 was determined | B | 5.89 | pKi | 1300 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 2693-2696 [PMID:11133070] |
| ChEMBL | Binding affinity against human Dopamine receptor D2 | B | 5.89 | pKi | 1300 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Displacement of [3H]-dofetilide to HEK cells stably expressing hERG voltage-gated IKr potassium channel Kv11.1 | B | 5.96 | pKi | 1100 | nM | Ki | J Med Chem (2002) 45: 492-503 [PMID:11784153] |
| ChEMBL | Binding affinity against human IKr channel | B | 5.96 | pKi | 1100 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598] |
| ChEMBL | Inhibition of human ERG channel | B | 5.96 | pKi | 1100 | nM | Ki | J Med Chem (2009) 52: 4266-4276 [PMID:19534531] |
| ChEMBL | Displacement of [3H]-dofetilide from human ERG receptor expressed HEK cells | B | 5.96 | pKi | 1100 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3708-3712 [PMID:20493697] |
| H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] | ||||||||
| ChEMBL | Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay | F | 6 | pKi | 1000 | nM | Ki | J Med Chem (2010) 53: 7778-7795 [PMID:20942472] |
| ChEMBL | PDSP Secondary Binding target: HRH1 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity. | B | 6.88 | pKi | 132.48 | nM | Ki | EUbOPEN Chemogenomics Library - PDSP Secondary Binding |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | PDSP Secondary Binding target: OPRK1 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity. | B | 6.99 | pKi | 102.71 | nM | Ki | EUbOPEN Chemogenomics Library - PDSP Secondary Binding |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5-HT1A receptor by competitive binding experiment | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Binding affinity to human brain homogenate 5-HT2A assessed as dissociation constant by quantitative autoradiographic analysis | B | 9.85 | pKd | 0.14 | nM | Kd | J Med Chem (2022) 65: 10755-10808 [PMID:35939391] |
| ChEMBL | Binding affinity for human 5-hydroxytryptamine 2A receptor | B | 8.82 | pKi | 1.5 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| ChEMBL | PDSP Secondary Binding target: HTR2A - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity. | B | 9.1 | pKi | 0.79 | nM | Ki | EUbOPEN Chemogenomics Library - PDSP Secondary Binding |
| ChEMBL | Binding affinity to 5HT2A receptor | B | 9.24 | pKi | 0.57 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1515-1519 [PMID:18187324] |
| ChEMBL | Binding affinity against 5-hydroxytryptamine 2A receptor in humans | B | 9.44 | pKi | 0.36 | nM | Ki | J Med Chem (2002) 45: 2319-2324 [PMID:12014970] |
| ChEMBL | Binding affinity against human 5-hydroxytryptamine 2A receptor | B | 9.51 | pKi | 0.31 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598] |
| ChEMBL | Binding affinity for displacement of [3H]ketanserin to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cells | B | 9.51 | pKi | 0.31 | nM | Ki | J Med Chem (2002) 45: 492-503 [PMID:11784153] |
| ChEMBL | Displacement of [3H]- ketanserin from human 5HT2A receptor expressed CHO cells | B | 9.51 | pKi | 0.31 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3708-3712 [PMID:20493697] |
| ChEMBL | Ability to displace [3H]ketanserin from CHO cells expressing human 5-hydroxytryptamine 2A receptor was determined | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 2693-2696 [PMID:11133070] |
| ChEMBL | Antagonist activity at human 5HT2A receptor expressed in HEK cells assessed as inhibition of intracellular calcium accumulation by aequorin assay | F | 10 | pKi | 0.1 | nM | Ki | J Med Chem (2010) 53: 7778-7795 [PMID:20942472] |
| ChEMBL | Antagonist activity at human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium release preincubated for 15 mins followed by 5-HT addition measured every 1.7 secs for 60 secs by calcium 4 dye-based FLIPR assay | F | 8.32 | pIC50 | 4.8 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1381-1385 [PMID:29555153] |
| ChEMBL | Antagonist activity at human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium release preincubated for 15 mins followed by 5-HT addition measured every 1.7 secs for 60 secs by calcium 4 dye-based FLIPR assay | F | 8.32 | pIC50 | 4.79 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1381-1385 [PMID:29555153] |
| GtoPdb | - | - | 9.3 | pIC50 | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Mol Pharmacol (2001) 60: 690-699 [PMID:11562430]; Br J Pharmacol (1999) 126: 572-4 [PMID:10188965] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| ChEMBL | Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells | B | 8.68 | pKi | 2.1 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1515-1519 [PMID:18187324] |
| ChEMBL | Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells by liquid scintillation analyser | B | 8.68 | pKi | 2.1 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| ChEMBL | Binding affinity towards rat 5-hydroxytryptamine 2A receptor | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| ChEMBL | Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells by liquid scintillation analyser | B | 9.42 | pKi | 0.38 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| ChEMBL | Displacement of [3H]MDL100907 from rat cortical membrane 5HT2A receptor | B | 9.44 | pKi | 0.36 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| ChEMBL | Binding affinity against rat 5-hydroxytryptamine 2A receptor | B | 10 | pKi | 0.1 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598] |
| ChEMBL | Binding affinity for displacement of [3H]ketanserin to rat 5-hydroxytryptamine 2A receptor stably expressed in CHO cells | B | 10 | pKi | 0.1 | nM | Ki | J Med Chem (2002) 45: 492-503 [PMID:11784153] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay | F | 5.9 | pKi | 1258.93 | nM | Ki | J Med Chem (2010) 53: 7778-7795 [PMID:20942472] |
| GtoPdb | - | - | 6 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Br J Pharmacol (1999) 126: 572-4 [PMID:10188965] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Antagonist activity at human 5HT2C receptor expressed in human SH-SY5Y cells by FLIPR assay | F | 6.5 | pKi | 316.23 | nM | Ki | J Med Chem (2010) 53: 7778-7795 [PMID:20942472] |
| ChEMBL | PDSP Secondary Binding target: HTR2C - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity. | B | 6.94 | pKi | 113.89 | nM | Ki | EUbOPEN Chemogenomics Library - PDSP Secondary Binding |
| ChEMBL | Binding affinity to 5HT2C receptor by competitive binding experiment | B | 6.97 | pKi | 107 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| GtoPdb | - | - | 7.7 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Br J Pharmacol (1999) 126: 572-4 [PMID:10188965] |
| ChEMBL | Binding affinity for displacement of [3H]mesulergine to human 5-hydroxytryptamine 2C receptor stably expressed in CHO cells | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (2002) 45: 492-503 [PMID:11784153] |
| ChEMBL | Binding affinity against human 5-hydroxytryptamine 2c receptor | B | 7.89 | pKi | 13 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598] |
| ChEMBL | Displacement of [3H]mesulergine from human 5HT2C receptor expressed CHO cells | B | 7.89 | pKi | 13 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3708-3712 [PMID:20493697] |
| σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] | ||||||||
| ChEMBL | PDSP Secondary Binding target: TMEM97 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity. | B | 6.69 | pKi | 204.97 | nM | Ki | EUbOPEN Chemogenomics Library - PDSP Secondary Binding |
| Kv7.1/Voltage-gated potassium channel subunit Kv7.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1866] [GtoPdb: 560] [UniProtKB: P51787] | ||||||||
| ChEMBL | Binding affinity at Voltage-gated potassium channel | B | 5.97 | pKi | 1060 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
