volinanserin [Ligand Id: 185] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL74355 (M-100907, M100907, Mdl-100907, MDL-100.907, MDL-100907, MDL100.907, Volinanserin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity to dopamine D2 receptor by competitive binding experiment | B | 5.65 | pKi | 2250 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| ChEMBL | Binding affinity for displacement of [3H]spiperone to human dopamine D2 (hD2) receptors stably expressed in CHO cells | B | 5.89 | pKi | 1300 | nM | Ki | J Med Chem (2002) 45: 492-503 [PMID:11784153] |
| ChEMBL | Ability to displace [3H]-spiperone from CHO cells expressing human Dopamine receptor D2 was determined | B | 5.89 | pKi | 1300 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 2693-2696 [PMID:11133070] |
| ChEMBL | Binding affinity against human Dopamine receptor D2 | B | 5.89 | pKi | 1300 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Displacement of [3H]-dofetilide to HEK cells stably expressing hERG voltage-gated IKr potassium channel Kv11.1 | B | 5.96 | pKi | 1100 | nM | Ki | J Med Chem (2002) 45: 492-503 [PMID:11784153] |
| ChEMBL | Binding affinity against human IKr channel | B | 5.96 | pKi | 1100 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598] |
| ChEMBL | Inhibition of human ERG channel | B | 5.96 | pKi | 1100 | nM | Ki | J Med Chem (2009) 52: 4266-4276 [PMID:19534531] |
| ChEMBL | Displacement of [3H]-dofetilide from human ERG receptor expressed HEK cells | B | 5.96 | pKi | 1100 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3708-3712 [PMID:20493697] |
| H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] | ||||||||
| ChEMBL | Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay | F | 6 | pKi | 1000 | nM | Ki | J Med Chem (2010) 53: 7778-7795 [PMID:20942472] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5-HT1A receptor by competitive binding experiment | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Binding affinity for human 5-hydroxytryptamine 2A receptor | B | 8.82 | pKi | 1.5 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| ChEMBL | Binding affinity to 5HT2A receptor | B | 9.24 | pKi | 0.57 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1515-1519 [PMID:18187324] |
| ChEMBL | Binding affinity against 5-hydroxytryptamine 2A receptor in humans | B | 9.44 | pKi | 0.36 | nM | Ki | J Med Chem (2002) 45: 2319-2324 [PMID:12014970] |
| ChEMBL | Binding affinity for displacement of [3H]ketanserin to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cells | B | 9.51 | pKi | 0.31 | nM | Ki | J Med Chem (2002) 45: 492-503 [PMID:11784153] |
| ChEMBL | Binding affinity against human 5-hydroxytryptamine 2A receptor | B | 9.51 | pKi | 0.31 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598] |
| ChEMBL | Displacement of [3H]- ketanserin from human 5HT2A receptor expressed CHO cells | B | 9.51 | pKi | 0.31 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3708-3712 [PMID:20493697] |
| ChEMBL | Ability to displace [3H]ketanserin from CHO cells expressing human 5-hydroxytryptamine 2A receptor was determined | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 2693-2696 [PMID:11133070] |
| ChEMBL | Antagonist activity at human 5HT2A receptor expressed in HEK cells assessed as inhibition of intracellular calcium accumulation by aequorin assay | F | 10 | pKi | 0.1 | nM | Ki | J Med Chem (2010) 53: 7778-7795 [PMID:20942472] |
| ChEMBL | Antagonist activity at human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium release preincubated for 15 mins followed by 5-HT addition measured every 1.7 secs for 60 secs by calcium 4 dye-based FLIPR assay | F | 8.32 | pIC50 | 4.8 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1381-1385 [PMID:29555153] |
| ChEMBL | Antagonist activity at human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium release preincubated for 15 mins followed by 5-HT addition measured every 1.7 secs for 60 secs by calcium 4 dye-based FLIPR assay | F | 8.32 | pIC50 | 4.79 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1381-1385 [PMID:29555153] |
| GtoPdb | - | - | 9.3 | pIC50 | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Mol Pharmacol (2001) 60: 690-699 [PMID:11562430]; Br J Pharmacol (1999) 126: 572-4 [PMID:10188965] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| ChEMBL | Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells | B | 8.68 | pKi | 2.1 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1515-1519 [PMID:18187324] |
| ChEMBL | Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells by liquid scintillation analyser | B | 8.68 | pKi | 2.1 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| ChEMBL | Binding affinity towards rat 5-hydroxytryptamine 2A receptor | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| ChEMBL | Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells by liquid scintillation analyser | B | 9.42 | pKi | 0.38 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| ChEMBL | Displacement of [3H]MDL100907 from rat cortical membrane 5HT2A receptor | B | 9.44 | pKi | 0.36 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| ChEMBL | Binding affinity against rat 5-hydroxytryptamine 2A receptor | B | 10 | pKi | 0.1 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598] |
| ChEMBL | Binding affinity for displacement of [3H]ketanserin to rat 5-hydroxytryptamine 2A receptor stably expressed in CHO cells | B | 10 | pKi | 0.1 | nM | Ki | J Med Chem (2002) 45: 492-503 [PMID:11784153] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay | F | 5.9 | pKi | 1258.93 | nM | Ki | J Med Chem (2010) 53: 7778-7795 [PMID:20942472] |
| GtoPdb | - | - | 6 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Br J Pharmacol (1999) 126: 572-4 [PMID:10188965] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Antagonist activity at human 5HT2C receptor expressed in human SH-SY5Y cells by FLIPR assay | F | 6.5 | pKi | 316.23 | nM | Ki | J Med Chem (2010) 53: 7778-7795 [PMID:20942472] |
| ChEMBL | Binding affinity to 5HT2C receptor by competitive binding experiment | B | 6.97 | pKi | 107 | nM | Ki | Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329] |
| GtoPdb | - | - | 7.7 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Br J Pharmacol (1999) 126: 572-4 [PMID:10188965] |
| ChEMBL | Binding affinity for displacement of [3H]mesulergine to human 5-hydroxytryptamine 2C receptor stably expressed in CHO cells | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (2002) 45: 492-503 [PMID:11784153] |
| ChEMBL | Binding affinity against human 5-hydroxytryptamine 2c receptor | B | 7.89 | pKi | 13 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598] |
| ChEMBL | Displacement of [3H]mesulergine from human 5HT2C receptor expressed CHO cells | B | 7.89 | pKi | 13 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 3708-3712 [PMID:20493697] |
| Kv7.1/Voltage-gated potassium channel subunit Kv7.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1866] [GtoPdb: 560] [UniProtKB: P51787] | ||||||||
| ChEMBL | Binding affinity at Voltage-gated potassium channel | B | 5.97 | pKi | 1060 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
