volinanserin [Ligand Id: 185] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL74355 (M-100907, M100907, Mdl-100907, MDL-100.907, MDL-100907, MDL100.907, Volinanserin)
  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
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  • H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
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  • Kv7.1/Voltage-gated potassium channel subunit Kv7.1 in Human [ChEMBL: CHEMBL1866] [GtoPdb: 560] [UniProtKB: P51787]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity to dopamine D2 receptor by competitive binding experiment B 5.65 pKi 2250 nM Ki Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329]
ChEMBL Binding affinity for displacement of [3H]spiperone to human dopamine D2 (hD2) receptors stably expressed in CHO cells B 5.89 pKi 1300 nM Ki J Med Chem (2002) 45: 492-503 [PMID:11784153]
ChEMBL Ability to displace [3H]-spiperone from CHO cells expressing human Dopamine receptor D2 was determined B 5.89 pKi 1300 nM Ki Bioorg Med Chem Lett (2000) 10: 2693-2696 [PMID:11133070]
ChEMBL Binding affinity against human Dopamine receptor D2 B 5.89 pKi 1300 nM Ki Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Displacement of [3H]-dofetilide to HEK cells stably expressing hERG voltage-gated IKr potassium channel Kv11.1 B 5.96 pKi 1100 nM Ki J Med Chem (2002) 45: 492-503 [PMID:11784153]
ChEMBL Binding affinity against human IKr channel B 5.96 pKi 1100 nM Ki Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598]
ChEMBL Inhibition of human ERG channel B 5.96 pKi 1100 nM Ki J Med Chem (2009) 52: 4266-4276 [PMID:19534531]
ChEMBL Displacement of [3H]-dofetilide from human ERG receptor expressed HEK cells B 5.96 pKi 1100 nM Ki Bioorg Med Chem Lett (2010) 20: 3708-3712 [PMID:20493697]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assay F 6 pKi 1000 nM Ki J Med Chem (2010) 53: 7778-7795 [PMID:20942472]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity to 5-HT1A receptor by competitive binding experiment B 5 pKi >10000 nM Ki Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Binding affinity to human brain homogenate 5-HT2A assessed as dissociation constant by quantitative autoradiographic analysis B 9.85 pKd 0.14 nM Kd J Med Chem (2022) 65: 10755-10808 [PMID:35939391]
ChEMBL Binding affinity for human 5-hydroxytryptamine 2A receptor B 8.82 pKi 1.5 nM Ki J Med Chem (2001) 44: 477-501 [PMID:11170639]
ChEMBL Binding affinity to 5HT2A receptor B 9.24 pKi 0.57 nM Ki Bioorg Med Chem Lett (2008) 18: 1515-1519 [PMID:18187324]
ChEMBL Binding affinity against 5-hydroxytryptamine 2A receptor in humans B 9.44 pKi 0.36 nM Ki J Med Chem (2002) 45: 2319-2324 [PMID:12014970]
ChEMBL Binding affinity for displacement of [3H]ketanserin to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cells B 9.51 pKi 0.31 nM Ki J Med Chem (2002) 45: 492-503 [PMID:11784153]
ChEMBL Binding affinity against human 5-hydroxytryptamine 2A receptor B 9.51 pKi 0.31 nM Ki Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598]
ChEMBL Displacement of [3H]- ketanserin from human 5HT2A receptor expressed CHO cells B 9.51 pKi 0.31 nM Ki Bioorg Med Chem Lett (2010) 20: 3708-3712 [PMID:20493697]
ChEMBL Ability to displace [3H]ketanserin from CHO cells expressing human 5-hydroxytryptamine 2A receptor was determined B 9.52 pKi 0.3 nM Ki Bioorg Med Chem Lett (2000) 10: 2693-2696 [PMID:11133070]
ChEMBL Antagonist activity at human 5HT2A receptor expressed in HEK cells assessed as inhibition of intracellular calcium accumulation by aequorin assay F 10 pKi 0.1 nM Ki J Med Chem (2010) 53: 7778-7795 [PMID:20942472]
ChEMBL Antagonist activity at human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium release preincubated for 15 mins followed by 5-HT addition measured every 1.7 secs for 60 secs by calcium 4 dye-based FLIPR assay F 8.32 pIC50 4.8 nM IC50 Bioorg Med Chem Lett (2018) 28: 1381-1385 [PMID:29555153]
ChEMBL Antagonist activity at human recombinant 5-HT2A receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium release preincubated for 15 mins followed by 5-HT addition measured every 1.7 secs for 60 secs by calcium 4 dye-based FLIPR assay F 8.32 pIC50 4.79 nM IC50 Bioorg Med Chem Lett (2018) 28: 1381-1385 [PMID:29555153]
GtoPdb - - 9.3 pIC50 - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733];
Mol Pharmacol (2001) 60: 690-699 [PMID:11562430];
Br J Pharmacol (1999) 126: 572-4 [PMID:10188965]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells B 8.68 pKi 2.1 nM Ki Bioorg Med Chem Lett (2008) 18: 1515-1519 [PMID:18187324]
ChEMBL Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells by liquid scintillation analyser B 8.68 pKi 2.1 nM Ki Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329]
ChEMBL Binding affinity towards rat 5-hydroxytryptamine 2A receptor B 8.85 pKi 1.4 nM Ki J Med Chem (2001) 44: 477-501 [PMID:11170639]
ChEMBL Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells by liquid scintillation analyser B 9.42 pKi 0.38 nM Ki Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329]
ChEMBL Displacement of [3H]MDL100907 from rat cortical membrane 5HT2A receptor B 9.44 pKi 0.36 nM Ki Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329]
ChEMBL Binding affinity against rat 5-hydroxytryptamine 2A receptor B 10 pKi 0.1 nM Ki Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598]
ChEMBL Binding affinity for displacement of [3H]ketanserin to rat 5-hydroxytryptamine 2A receptor stably expressed in CHO cells B 10 pKi 0.1 nM Ki J Med Chem (2002) 45: 492-503 [PMID:11784153]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay F 5.9 pKi 1258.93 nM Ki J Med Chem (2010) 53: 7778-7795 [PMID:20942472]
GtoPdb - - 6 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733];
Br J Pharmacol (1999) 126: 572-4 [PMID:10188965]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Antagonist activity at human 5HT2C receptor expressed in human SH-SY5Y cells by FLIPR assay F 6.5 pKi 316.23 nM Ki J Med Chem (2010) 53: 7778-7795 [PMID:20942472]
ChEMBL Binding affinity to 5HT2C receptor by competitive binding experiment B 6.97 pKi 107 nM Ki Bioorg Med Chem (2009) 17: 2989-3002 [PMID:19329329]
GtoPdb - - 7.7 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733];
Br J Pharmacol (1999) 126: 572-4 [PMID:10188965]
ChEMBL Binding affinity for displacement of [3H]mesulergine to human 5-hydroxytryptamine 2C receptor stably expressed in CHO cells B 7.89 pKi 13 nM Ki J Med Chem (2002) 45: 492-503 [PMID:11784153]
ChEMBL Binding affinity against human 5-hydroxytryptamine 2c receptor B 7.89 pKi 13 nM Ki Bioorg Med Chem Lett (2005) 15: 3665-3669 [PMID:15993598]
ChEMBL Displacement of [3H]mesulergine from human 5HT2C receptor expressed CHO cells B 7.89 pKi 13 nM Ki Bioorg Med Chem Lett (2010) 20: 3708-3712 [PMID:20493697]
Kv7.1/Voltage-gated potassium channel subunit Kv7.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1866] [GtoPdb: 560] [UniProtKB: P51787]
ChEMBL Binding affinity at Voltage-gated potassium channel B 5.97 pKi 1060 nM Ki J Med Chem (2001) 44: 477-501 [PMID:11170639]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]