Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL494897 (BPH-715) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
ChEMBL | Inhibition of human FPPS using FPP and [3H]-IPP as substrate incubated for 30 mins prior to substrate addition measured after 20 mins by scintillation counting | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2012) 55: 3201-3215 [PMID:22390415] |
ChEMBL | Inhibition of human FPPS using GPP and [3H]IPP as substrate by scintillation counting | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2012) 20: 5583-5591 [PMID:22884353] |
ChEMBL | Inhibition of human FPPS using IPP and GPP | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2019) 62: 2564-2581 [PMID:30730737] |
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] | ||||||||
ChEMBL | Inhibition of human GGPPS | B | 5.16 | pKi | 6900 | nM | Ki | Antimicrob Agents Chemother (2010) 54: 2987-2993 [PMID:20457823] |
GtoPdb | Inhibition of human recombinant geranylgeranyl diphosphate synthase | - | 6.55 | pIC50 | 280 | nM | IC50 | J Med Chem (2008) 51: 5594-607 [PMID:18800762] |
ChEMBL | Inhibition of human recombinant geranylgeranyl diphosphate synthase | B | 6.55 | pIC50 | 280 | nM | IC50 | J Med Chem (2008) 51: 5594-5607 [PMID:18800762] |
ChEMBL | Inhibition of human recombinant GGPPS using [14C]-IPP as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by scintillation counting | B | 6.55 | pIC50 | 280 | nM | IC50 | J Med Chem (2012) 55: 3201-3215 [PMID:22390415] |
ChEMBL | Inhibition of human recombinant GGPS using [14C]-IPP as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by scintillation counting | B | 6.55 | pIC50 | 280 | nM | IC50 | Bioorg Med Chem (2012) 20: 5583-5591 [PMID:22884353] |
ChEMBL | Inhibition of human GGPPS | B | 6.55 | pIC50 | 280 | nM | IC50 | J Med Chem (2019) 62: 2564-2581 [PMID:30730737] |
ChEMBL | Inhibition of human recombinant geranylgeranyl diphosphate synthase | B | 6.6 | pIC50 | 251.19 | nM | IC50 | J Med Chem (2008) 51: 5594-5607 [PMID:18800762] |
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
ChEMBL | Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR | F | 5 | pIC50 | 10000 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 2987-2993 [PMID:20457823] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as suppression of parasitemia by microscopic analysis | F | 6.17 | pIC50 | 670 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 2987-2993 [PMID:20457823] |
ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2mef assessed as suppression of parasitemia by microscopic analysis | F | 6.23 | pIC50 | 590 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 2987-2993 [PMID:20457823] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]