ChEMBL ligand: CHEMBL494897 (BPH-715)
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] There should be some charts here, you may need to enable JavaScript!
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL	Inhibition of human FPPS using FPP and [3H]-IPP as substrate incubated for 30 mins prior to substrate addition measured after 20 mins by scintillation counting	B	7	pIC50	100	nM	IC50	J Med Chem (2012) 55: 3201-3215 [PMID:22390415]
ChEMBL	Inhibition of human FPPS using GPP and [3H]IPP as substrate by scintillation counting	B	7	pIC50	100	nM	IC50	Bioorg Med Chem (2012) 20: 5583-5591 [PMID:22884353]
ChEMBL	Inhibition of human FPPS using IPP and GPP	B	7	pIC50	100	nM	IC50	J Med Chem (2019) 62: 2564-2581 [PMID:30730737]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
ChEMBL	Inhibition of human GGPPS	B	5.16	pKi	6900	nM	Ki	Antimicrob Agents Chemother (2010) 54: 2987-2993 [PMID:20457823]
GtoPdb	Inhibition of human recombinant geranylgeranyl diphosphate synthase	-	6.55	pIC50	280	nM	IC50	J Med Chem (2008) 51: 5594-607 [PMID:18800762]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	6.55	pIC50	280	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
ChEMBL	Inhibition of human recombinant GGPPS using [14C]-IPP as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by scintillation counting	B	6.55	pIC50	280	nM	IC50	J Med Chem (2012) 55: 3201-3215 [PMID:22390415]
ChEMBL	Inhibition of human recombinant GGPS using [14C]-IPP as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by scintillation counting	B	6.55	pIC50	280	nM	IC50	Bioorg Med Chem (2012) 20: 5583-5591 [PMID:22884353]
ChEMBL	Inhibition of human GGPPS	B	6.55	pIC50	280	nM	IC50	J Med Chem (2019) 62: 2564-2581 [PMID:30730737]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	6.6	pIC50	251.19	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR	F	5	pIC50	10000	nM	IC50	Antimicrob Agents Chemother (2010) 54: 2987-2993 [PMID:20457823]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as suppression of parasitemia by microscopic analysis	F	6.17	pIC50	670	nM	IC50	Antimicrob Agents Chemother (2010) 54: 2987-2993 [PMID:20457823]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2mef assessed as suppression of parasitemia by microscopic analysis	F	6.23	pIC50	590	nM	IC50	Antimicrob Agents Chemother (2010) 54: 2987-2993 [PMID:20457823]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]