AR-C67085 [Ligand Id: 1756] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL336292 (AR-C67085)
  • P2Y11 receptor/Purinergic receptor P2Y11 in Human [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91]
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  • P2Y12 receptor/Purinergic receptor P2Y12 in Human [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
P2Y11 receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91]
ChEMBL Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) F 5.82 pEC50 1500 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
GtoPdb - - 8.52 pEC50 - - - Br J Pharmacol (1999) 128: 1199-206 [PMID:10578132];
J Mol Cell Cardiol (2005) 39: 223-30 [PMID:15893764]
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
GtoPdb - - 8.2 pKd - - - Future Med Chem (2013) 5: 431-49 [PMID:23495690]
ChEMBL Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric method B 8.6 pIC50 2.51 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 2739-2754 [PMID:27133596]
ChEMBL The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 12 (P2Y12) F 8.89 pEC50 1.3 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]