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ChEMBL ligand: CHEMBL336292 (AR-C67085) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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P2Y11 receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91] | ||||||||
ChEMBL | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) | F | 5.82 | pEC50 | 1500 | nM | EC50 | J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051] |
GtoPdb | - | - | 8.52 | pEC50 | - | - | - |
Br J Pharmacol (1999) 128: 1199-206 [PMID:10578132]; J Mol Cell Cardiol (2005) 39: 223-30 [PMID:15893764] |
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] | ||||||||
GtoPdb | - | - | 8.2 | pKd | - | - | - | Future Med Chem (2013) 5: 431-49 [PMID:23495690] |
ChEMBL | Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric method | B | 8.6 | pIC50 | 2.51 | nM | IC50 | Bioorg. Med. Chem. Lett. (2016) 26: 2739-2754 [PMID:27133596] |
ChEMBL | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 12 (P2Y12) | F | 8.89 | pEC50 | 1.3 | nM | EC50 | J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]