compound 35 [PMID: 19191557] [Ligand Id: 3122] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1208063 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| squalene synthase in Human [GtoPdb: 645] [UniProtKB: P37268] | ||||||||
| GtoPdb | Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21 (DE3) cells assessed as formation of 1,10-dioic acid metabolite by liquid scintillation | - | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2009) 52: 976-88 [PMID:19191557] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]
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