glycopyrrolate [Ligand Id: 7459] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1201335 (Glycopyrrolate cation, Glycopyrrolate ion, Glycopyrronium, Glycopyrronium cation, Glycopyrronium, erythro-, Glycopyrronium ion) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| GtoPdb | - | - | 9.5 | pIC50 | - | - | IC50 |
Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043]; J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200] |
| ChEMBL | Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs | B | 9.8 | pIC50 | 0.16 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 7440-7446 [PMID:22047691] |
| M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
| ChEMBL | Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs | B | 9.6 | pIC50 | 0.25 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 7440-7446 [PMID:22047691] |
| GtoPdb | Assay uses glycopyrronium bromide | - | 9.8 | pIC50 | - | - | IC50 |
Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043]; J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200] |
| ChEMBL | Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method | B | 9.9 | pIC50 | 0.13 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 6248-6253 [PMID:24144851] |
| M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
| GtoPdb | Assay uses glycopyrronium bromide | - | 10.1 | pIC50 | - | - | IC50 |
Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043]; J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200] |
| M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
| GtoPdb | - | - | 10 | pKi | - | - | - |
Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043]; J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200] |
| M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
| GtoPdb | - | - | 9.9 | pKi | - | - | - |
Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043]; J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
