glycopyrrolate [Ligand Id: 7459] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1201335 (Glycopyrronium)
  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1201335_lig_chart_1 Muscarinic acetylcholine receptor M2 Human
There should be some charts here, you may need to enable JavaScript!
  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
  • This target only has 0 pki data point
  • 0
2 CHEMBL1201335_lig_chart_2 Muscarinic acetylcholine receptor M3 Human
There should be some charts here, you may need to enable JavaScript!
  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
  • This target only has 0 pki data point
  • 0
3 CHEMBL1201335_lig_chart_3 M1 receptor Human
There should be some charts here, you may need to enable JavaScript!
  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
  • This target only has 1 pki data point
  • 10
4 CHEMBL1201335_lig_chart_4 M4 receptor Human
There should be some charts here, you may need to enable JavaScript!
  • M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
  • This target only has 1 pki data point
  • 9.9
5 CHEMBL1201335_lig_chart_5 M5 receptor Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 9.5 pIC50 - - IC50 Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043];
J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200]
ChEMBL Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs B 9.8 pIC50 0.16 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 7440-7446 [PMID:22047691]
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs B 9.6 pIC50 0.25 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 7440-7446 [PMID:22047691]
GtoPdb Assay uses glycopyrronium bromide - 9.8 pIC50 - - IC50 Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043];
J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200]
ChEMBL Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method B 9.9 pIC50 0.13 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 6248-6253 [PMID:24144851]
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb Assay uses glycopyrronium bromide - 10.1 pIC50 - - IC50 Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043];
J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 10 pKi - - - Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043];
J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb - - 9.9 pKi - - - Bioorg Med Chem Lett (2010) 20: 7458-61 [PMID:21036043];
J Pharmacol Exp Ther (2012) 343: 520-8 [PMID:22854200]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]