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pegpleranib   Click here for help

GtoPdb Ligand ID: 13532

Synonyms: E-01AJ | E-10030 | E01AJ | E10030 | Fovista® | X-01E | X01E
Compound class: Nucleic acid
Comment: Pegpleranib (E10030) is a 32-mer pegylated DNA aptamer that selectively binds to PDGF-BB and PDGF-AB homo- and hetero-dimers. It prevents PDGF binding to its cognate PDGF receptors. Blocking receptor activation leads to the death of capillary pericytes. This mechanism was investigated as a disruptor of vessel formation in neovascular age related macular degeneration. Pegpleranib is formulated as a sodium adduct for therapeutic administration (see DBSALT002614).
Classification Click here for help
Compound class Nucleic acid
Compound subclass Aptamer
Target Platelet-derived growth factor subunit B
International Nonproprietary Names Click here for help
INN number INN
10044 pegpleranib
Synonyms Click here for help
E-01AJ | E-10030 | E01AJ | E10030 | Fovista® | X-01E | X01E
Database Links Click here for help
CAS Registry No. 1449390-73-1 (source: WHO INN record)
ChEMBL Ligand CHEMBL3301576
DrugBank Ligand DBSALT002614
GtoPdb PubChem SID 500839942
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