NBI-34041 [Ligand Id: 10375] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL188907 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CRF1 receptor/Corticotropin releasing factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998] | ||||||||
| GtoPdb | - | - | 8.29 | pKi | 5.1 | nM | Ki | J Med Chem (2005) 48: 5104-7 [PMID:16078829] |
| ChEMBL | Binding affinity for human corticotropin releasing factor receptor 1 expressed in LtK- cells using [125I]sauvagine | B | 8.3 | pKi | 5.01 | nM | Ki | J Med Chem (2005) 48: 5780-5793 [PMID:16134945] |
| ChEMBL | Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells | B | 8.35 | pKi | 4.5 | nM | Ki | J Med Chem (2005) 48: 5104-5107 [PMID:16078829] |
| ChEMBL | Antagonist activity at human CRF-1 receptor | F | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2011) 54: 4187-4206 [PMID:21618986] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
