glasdegib [Ligand Id: 8201] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2043437 (Glasdegib, PF-04449913, PF-4449913)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
SMO in Human [GtoPdb: 239] [UniProtKB: Q99835]
GtoPdb - - 8.3 pIC50 5 nM IC50 ACS Med Chem Lett (2012) 3: 106-11 [PMID:24900436]
SMO/Smoothened homolog in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6080] [GtoPdb: 239] [UniProtKB: P56726]
ChEMBL Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hrs by Gli-luciferase reporter assay B 8.3 pIC50 5 nM IC50 ACS Med Chem Lett (2012) 3: 106-111 [PMID:24900436]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]