pyridomycin [Ligand Id: 13449] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2323585 (Pyridomycin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Enoyl-[acyl-carrier-protein] reductase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1849] [UniProtKB: P9WGR1] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis wild type InhA | B | 5.19 | pKi | 6500 | nM | Ki | Eur J Med Chem (2020) 208: 112757-112757 [PMID:32883635] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis InhA S94A mutant assessed as NADH oxidation using 2-trans-dodecenoyl-coA as substrate measured every min for 30 mins by spectrophotometric analysis | B | 5.32 | pKi | 4800 | nM | Ki | ACS Med Chem Lett (2013) 4: 264-268 [PMID:24900646] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis InhA S94A | B | 5.34 | pKi | 4550 | nM | Ki | Eur J Med Chem (2020) 208: 112757-112757 [PMID:32883635] |
| ChEMBL | Inhibition of wild type Mycobacterium tuberculosis inhA | B | 5.22 | pIC50 | 6000 | nM | IC50 | J Med Chem (2013) 56: 8533-8542 [PMID:24107081] |
| ChEMBL | Inhibition of bacterial InhA harboring S94A mutant using 2-trans-octenoyl-CoA or 2-trans-dodecenoyl-CoA as substrate | B | 5.46 | pIC50 | 3430 | nM | IC50 | J Med Chem (2020) 63: 1105-1131 [PMID:31904960] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
