RV6153

Ligand id: 10163

Name: RV6153

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 152.43
Molecular weight 717.23
XLogP 5.88
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[[4-amino-3-(3-fluoro-5-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-[3-[2-(2-methoxyethoxy)ethoxy]prop-1-ynyl]-3-[[2-(trifluoromethyl)phenyl]methyl]quinazolin-4-one
Synonyms
RV-6153
Comments
RV6153 is a clinical stage PI3Kγδ inhibitor [1] that is being developed by Janssen Biotech subsidiary RespiVert. The chemical structure is claimed in patent US9227977B2 [2]. It is a derivative of RV1729. RV6153 is selective for PI3Kγδ over the α and β enzyme isoforms.
Database Links
BindingDB Ligand 200638
ChEMBL Ligand CHEMBL3934989
GtoPdb PubChem SID 381118873
PubChem CID 86268622
Search Google for chemical match using the InChIKey JTACVHJPXOKMTI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone JTACVHJPXOKMTI
Search UniChem for chemical match using the InChIKey JTACVHJPXOKMTI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone JTACVHJPXOKMTI