RV6153

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Ligands
RV6153

Ligand id: 10163

Name: RV6153

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	8
Hydrogen bond donors	2
Rotatable bonds	13
Topological polar surface area	152.43
Molecular weight	717.23
XLogP	5.88
No. Lipinski's rules broken	2

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic

IUPAC Name
2-[[4-amino-3-(3-fluoro-5-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-[3-[2-(2-methoxyethoxy)ethoxy]prop-1-ynyl]-3-[[2-(trifluoromethyl)phenyl]methyl]quinazolin-4-one

IUPAC Name

2-[[4-amino-3-(3-fluoro-5-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-[3-[2-(2-methoxyethoxy)ethoxy]prop-1-ynyl]-3-[[2-(trifluoromethyl)phenyl]methyl]quinazolin-4-one

Synonyms
RV-6153

Synonyms

RV-6153

Comments
RV6153 is a clinical stage PI3Kγδ inhibitor [1] that is being developed by Janssen Biotech subsidiary RespiVert. The chemical structure is claimed in patent US9227977B2 [2]. It is a derivative of RV1729. RV6153 is selective for PI3Kγδ over the α and β enzyme isoforms.

Comments

RV6153 is a clinical stage PI3Kγδ inhibitor [1] that is being developed by Janssen Biotech subsidiary RespiVert. The chemical structure is claimed in patent US9227977B2 [2]. It is a derivative of RV1729. RV6153 is selective for PI3Kγδ over the α and β enzyme isoforms.

Database Links
BindingDB Ligand	200638
ChEMBL Ligand	CHEMBL3934989
GtoPdb PubChem SID	381118873
PubChem CID	86268622
Search Google for chemical match using the InChIKey	JTACVHJPXOKMTI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone	JTACVHJPXOKMTI
Search UniChem for chemical match using the InChIKey	JTACVHJPXOKMTI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone	JTACVHJPXOKMTI