Ligand id: 10163

Name: RV6153

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 152.43
Molecular weight 717.23
XLogP 5.88
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Immunopharmacology Comments
RV6153 is a PI3Kγδ inhibitor that was developed as a potential treatment for uncontrolled asthma and COPD. Pharmacological inhibition of PI3K γ and δ isoforms reduces airway hyper-responsiveness, IgE release, pro-inflammatory cytokine expression, inflammatory cell accumulation into the lung and vascular permeability in preclinical model systems, and this mechanism has advanced to clinical evaluation in patients with inflammatory lung conditions such as asthma and COPD.