vibegron [Ligand Id: 10100] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2107826 (KRP-114V, Vibegron, MK-4618)
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
  • This target only has 0 pki data point
1 CHEMBL2107826_lig_chart_1 Beta-1 adrenergic receptor Human
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
  • This target only has 0 pki data point
2 CHEMBL2107826_lig_chart_2 Beta-2 adrenergic receptor Human
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  • β3-adrenoceptor in Monkey [GtoPdb: 30]
  • Beta-3 adrenergic receptor in Rhesus macaque [ChEMBL: CHEMBL3124732] [UniProtKB: Q28524]
  • β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
  • Beta-3 adrenergic receptor in Dog [ChEMBL: CHEMBL4400] [UniProtKB: O02662]
  • β3-adrenoceptor/Beta-3 adrenergic receptor in Rat [ChEMBL: CHEMBL4031] [GtoPdb: 30] [UniProtKB: P26255]
  • This target only has 0 pki data point
3 CHEMBL2107826_lig_chart_3 β3-adrenoceptor MonkeyRhesus macaqueHumanDogRat
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  • Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
  • This target only has 0 pki data point
4 CHEMBL2107826_lig_chart_4 HERG Human
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
  • This target only has 0 pki data point
5 CHEMBL2107826_lig_chart_5 Serotonin transporter Human
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  • Nav1.5/Sodium channel protein type V alpha subunit in Human [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
  • This target only has 0 pki data point
6 CHEMBL2107826_lig_chart_6 Sodium channel protein type V alpha subunit Human
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  • Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
  • This target only has 0 pki data point
7 CHEMBL2107826_lig_chart_7 Voltage-gated L-type calcium channel alpha-1C subunit Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Displacement of [125]I-cyanopindolol from recombinant human beta1 adrenergic receptor after 1 hr by scintillation counting method B 4.7 pIC50 >20000 nM IC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Displacement of [125]I-cyanopindolol from human recombinant beta2 adrenergic receptor after 1 hr by scintillation counting method B 4.7 pIC50 >20000 nM IC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
β3-adrenoceptor in Monkey [GtoPdb: 30]
GtoPdb - - 9.24 pIC50 0.57 nM IC50 J. Med. Chem. (2016) 59: 609-23 [PMID:26709102]
Beta-3 adrenergic receptor in Rhesus macaque (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3124732] [UniProtKB: Q28524]
ChEMBL Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum B 8.15 pEC50 7.1 nM EC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
ChEMBL Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay B 9.24 pEC50 0.57 nM EC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
ChEMBL Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum B 8.8 pEC50 1.6 nM EC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
ChEMBL Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay B 8.96 pEC50 1.1 nM EC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
GtoPdb - - 8.96 pEC50 1.1 nM EC50 J. Med. Chem. (2016) 59: 609-23 [PMID:26709102]
Beta-3 adrenergic receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4400] [UniProtKB: O02662]
ChEMBL Agonist activity at dog beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay B 7.96 pEC50 11 nM EC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
β3-adrenoceptor/Beta-3 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4031] [GtoPdb: 30] [UniProtKB: P26255]
ChEMBL Agonist activity at rat beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum B 6.91 pEC50 122 nM EC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
ChEMBL Agonist activity at rat beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay B 7.07 pEC50 86 nM EC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
GtoPdb - - 7.07 pEC50 86 nM EC50 J. Med. Chem. (2016) 59: 609-23 [PMID:26709102]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Binding affinity to human ERG channel B 4.52 pIC50 >30000 nM IC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL Inhibition of human SERT expressed in HEK293 cells preincubated for 30 mins followed by fluorescent substrate addition measured after 30 mins by plate reader analysis B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
ChEMBL Inhibition of human Nav1.2 channel expressed in Xenopus oocytes by two-intracellular microelectrode voltage clamp method B 4.52 pIC50 >30000 nM IC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
ChEMBL Displacement of [3H]-diltiazem from human Cav1.2 channel B 4.52 pIC50 >30000 nM IC50 J. Med. Chem. (2016) 59: 609-623 [PMID:26709102]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]