ChEMBL ligand: CHEMBL2324924
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibition of P38alpha (unknown origin)	B	7.37	pIC50	43	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL	Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins	B	9	pIC50	1	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of wild type Abl1 kinase (unknown origin)	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
GtoPdb	-	-	9.3	pIC50	0.5	nM	IC50	J Med Chem (2013) 56: 3033-47 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase Q252H mutant (unknown origin)	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase T315I mutant (unknown origin)	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase Y253F mutant (unknown origin)	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase M351T mutant (unknown origin)	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase H396P mutant (unknown origin)	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins by platform assay	B	9.7	pIC50	0.2	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
ChEMBL	Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins by platform assay	B	8.7	pIC50	2	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
GtoPdb	-	-	9	pIC50	1	nM	IC50	J Med Chem (2013) 56: 3033-47 [PMID:23441572]
ChEMBL	Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins	B	9	pIC50	1	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]