ChEMBL ligand: CHEMBL2324924
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibition of P38alpha (unknown origin)	B	7.37	pIC50	43	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL	Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins	B	9	pIC50	1	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of wild type Abl1 kinase (unknown origin)	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
GtoPdb	-	-	9.3	pIC50	0.5	nM	IC50	J Med Chem (2013) 56: 3033-47 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase Q252H mutant (unknown origin)	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase T315I mutant (unknown origin)	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase Y253F mutant (unknown origin)	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase M351T mutant (unknown origin)	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase H396P mutant (unknown origin)	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL	Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins by platform assay	B	9.7	pIC50	0.2	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
ChEMBL	Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins by platform assay	B	8.7	pIC50	2	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]
GtoPdb	-	-	9	pIC50	1	nM	IC50	J Med Chem (2013) 56: 3033-47 [PMID:23441572]
ChEMBL	Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins	B	9	pIC50	1	nM	IC50	J Med Chem (2013) 56: 3033-3047 [PMID:23441572]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]