compound 24 [PMID: 23441572] [Ligand Id: 8147] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2324924
  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
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  • ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition of P38alpha (unknown origin) B 7.37 pIC50 43 nM IC50 J. Med. Chem. (2013) 56: 3033-3047 [PMID:23441572]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins B 9 pIC50 1 nM IC50 J. Med. Chem. (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL Inhibition of wild type Abl1 kinase (unknown origin) B 9.22 pIC50 0.6 nM IC50 J. Med. Chem. (2013) 56: 3033-3047 [PMID:23441572]
GtoPdb - - 9.3 pIC50 0.5 nM IC50 J Med Chem (2013) 56: 3033-47 [PMID:23441572]
ChEMBL Inhibition of Abl1 kinase Q252H mutant (unknown origin) B 9.3 pIC50 0.5 nM IC50 J. Med. Chem. (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL Inhibition of Abl1 kinase T315I mutant (unknown origin) B 9.4 pIC50 0.4 nM IC50 J. Med. Chem. (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL Inhibition of Abl1 kinase Y253F mutant (unknown origin) B 9.52 pIC50 0.3 nM IC50 J. Med. Chem. (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL Inhibition of Abl1 kinase M351T mutant (unknown origin) B 9.52 pIC50 0.3 nM IC50 J. Med. Chem. (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL Inhibition of Abl1 kinase H396P mutant (unknown origin) B 9.52 pIC50 0.3 nM IC50 J. Med. Chem. (2013) 56: 3033-3047 [PMID:23441572]
ChEMBL Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins by platform assay B 9.7 pIC50 0.2 nM IC50 J. Med. Chem. (2013) 56: 3033-3047 [PMID:23441572]
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
ChEMBL Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins by platform assay B 8.7 pIC50 2 nM IC50 J. Med. Chem. (2013) 56: 3033-3047 [PMID:23441572]
GtoPdb - - 9 pIC50 1 nM IC50 J Med Chem (2013) 56: 3033-47 [PMID:23441572]
ChEMBL Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins B 9 pIC50 1 nM IC50 J. Med. Chem. (2013) 56: 3033-3047 [PMID:23441572]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]