ChEMBL ligand: CHEMBL2364605 (Cebranopadol, GRT-6005, GRT6005)
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor in Rat [GtoPdb: 319] [UniProtKB: P33535] There should be some charts here, you may need to enable JavaScript!
NOP receptor/Nociceptin receptor in Human [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] NOP receptor in Rat [GtoPdb: 320] [UniProtKB: P35370] There should be some charts here, you may need to enable JavaScript!
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145] κ receptor in Rat [GtoPdb: 318] [UniProtKB: P34975] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb	Radioligand binding assay	-	9.15	pKi	0.7	nM	Ki	J Pharmacol Exp Ther (2014) 349: 535-48 [PMID:24713140]
ChEMBL	Displacement of [N-allyl-2,3-3H]naloxone from recombinant human mu opioid receptor expressed in CHOK1 cell membranes after 90 mins by scintillation counting method	B	9.15	pKi	0.7	nM	Ki	J Med Chem (2016) 59: 7011-7028 [PMID:26878436]
ChEMBL	Agonist activity at recombinant human mu opioid receptor expressed in CHOK1 cell membranes after 45 mins by GTPgamma(35)S binding assay	B	8.92	pEC50	1.2	nM	EC50	J Med Chem (2016) 59: 7011-7028 [PMID:26878436]
μ receptor in Rat [GtoPdb: 319] [UniProtKB: P33535]
GtoPdb	Radioligand binding assay	-	8.62	pKi	2.4	nM	Ki	J Pharmacol Exp Ther (2014) 349: 535-48 [PMID:24713140]
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146]
ChEMBL	Displacement of [leucyl-3H]nociceptin from human nociceptin opioid receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting method	B	9.05	pKi	0.9	nM	Ki	J Med Chem (2016) 59: 7011-7028 [PMID:26878436]
GtoPdb	Radioligand binding assay	-	9.05	pKi	0.9	nM	Ki	J Pharmacol Exp Ther (2014) 349: 535-48 [PMID:24713140]
ChEMBL	Agonist activity at recombinant human nociceptin opioid receptor expressed in CHOK1 cell membranes after 45 mins by GTPgamma(35)S binding assay	B	7.89	pEC50	13	nM	EC50	J Med Chem (2016) 59: 7011-7028 [PMID:26878436]
GtoPdb	Stimulation of GTP-γ35S binding	-	7.89	pEC50	13	nM	EC50	J Pharmacol Exp Ther (2014) 349: 535-48 [PMID:24713140]
NOP receptor in Rat [GtoPdb: 320] [UniProtKB: P35370]
GtoPdb	Radioligand binding assay	-	9	pKi	1	nM	Ki	J Pharmacol Exp Ther (2014) 349: 535-48 [PMID:24713140]
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb	Radioligand binding assay	-	7.74	pKi	18	nM	Ki	J Pharmacol Exp Ther (2014) 349: 535-48 [PMID:24713140]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb	Radioligand binding assay	-	8.59	pKi	2.6	nM	Ki	J Pharmacol Exp Ther (2014) 349: 535-48 [PMID:24713140]
κ receptor in Rat [GtoPdb: 318] [UniProtKB: P34975]
GtoPdb	Radioligand binding assay	-	7.19	pKi	64	nM	Ki	J Pharmacol Exp Ther (2014) 349: 535-48 [PMID:24713140]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]