ChEMBL ligand: CHEMBL2216824
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
ChEMBL	Inhibition of JNK1	B	8.33	pIC50	4.7	nM	IC50	J Med Chem (2012) 55: 6243-6262 [PMID:22621397]
ChEMBL	Inhibition of JNK1 (unknown origin) after 1 hr incubation	B	8.33	pIC50	4.7	nM	IC50	J Med Chem (2015) 58: 72-95 [PMID:25415535]
GtoPdb	-	-	8.33	pIC50	4.7	nM	IC50	Chem Biol (2012) 19: 140-54 [PMID:22284361]
ChEMBL	Inhibition of JNK1 (unknown origin) after 1 hr	B	9	pIC50	1	nM	IC50	J Med Chem (2017) 60: 839-885 [PMID:27996267]
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
ChEMBL	Inhibition of JNK2	B	7.73	pIC50	18.7	nM	IC50	J Med Chem (2012) 55: 6243-6262 [PMID:22621397]
GtoPdb	-	-	7.73	pIC50	18.7	nM	IC50	Chem Biol (2012) 19: 140-54 [PMID:22284361]
ChEMBL	Inhibition of JNK2 (unknown origin) after 1 hr incubation	B	9	pIC50	1	nM	IC50	J Med Chem (2015) 58: 72-95 [PMID:25415535]
ChEMBL	Inhibition of JNK2 (unknown origin) after 1 hr	B	9	pIC50	1	nM	IC50	J Med Chem (2017) 60: 839-885 [PMID:27996267]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL	Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubation	B	6.31	pIC50	486	nM	IC50	J Med Chem (2015) 58: 72-95 [PMID:25415535]
ChEMBL	Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubation	B	6.47	pIC50	338	nM	IC50	J Med Chem (2015) 58: 72-95 [PMID:25415535]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Chem Biol (2012) 19: 140-54 [PMID:22284361]
ChEMBL	Inhibition of JNK3 (unknown origin) after 1 hr incubation	B	9	pIC50	1	nM	IC50	J Med Chem (2015) 58: 72-95 [PMID:25415535]
ChEMBL	Inhibition of JNK3 (unknown origin) after 1 hr by FRET-based assay	B	9	pIC50	1	nM	IC50	J Med Chem (2017) 60: 839-885 [PMID:27996267]
ChEMBL	Inhibition of JNK3	B	9.01	pIC50	0.98	nM	IC50	J Med Chem (2012) 55: 6243-6262 [PMID:22621397]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]