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ChEMBL ligand: CHEMBL1808388 (Bexagliflozin, EGT-0001442, EGT0001442, EGT-1442, EGT1442, THR-1442, THR1442) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Sodium/glucose cotransporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4979] [GtoPdb: 915] [UniProtKB: P13866] | ||||||||
GtoPdb | - | - | 5.25 | pIC50 | 5600 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4465-70 [PMID:21737266] |
ChEMBL | Inhibition of human SGLT1 expressed in human 293 cells assessed as inhibition of [14C]-methyl-alpha-D-glucopyranoside uptake after 1.5 hrs by scintillation counting in presence of 25 % human plasma | B | 5.25 | pIC50 | 5600 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4465-4470 [PMID:21737266] |
Sodium/glucose cotransporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3884] [GtoPdb: 916] [UniProtKB: P31639] | ||||||||
ChEMBL | Inhibition of human SGLT2 expressed in african green monkey COS7 cells assessed as inhibition of [14C]-methyl-alpha-D-glucopyranoside uptake after 2 hrs by scintillation counting in presence of 25 % human plasma | B | 8.64 | pIC50 | 2.3 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4465-4470 [PMID:21737266] |
GtoPdb | - | - | 8.64 | pIC50 | 2.3 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4465-70 [PMID:21737266] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]