capmatinib   Click here for help

GtoPdb Ligand ID: 7904

Synonyms: INC280 | INCB28060 | Tabrecta®
Approved drug
capmatinib is an approved drug (FDA (2020), EMA (2022))
Compound class: Synthetic organic
Comment: Capmatinib (NCB28060) is a novel, oral, ATP-competitive inhibitor of c-MET that was developed by Novartis [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 85.07
Molecular weight 412.14
XLogP 3.28
No. Lipinski's rules broken 0
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Canonical SMILES CNC(=O)c1ccc(cc1F)c1cnc2n(n1)c(cn2)Cc1ccc2c(c1)cccn2
Isomeric SMILES CNC(=O)c1ccc(cc1F)c1cnc2n(n1)c(cn2)Cc1ccc2c(c1)cccn2
InChI InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2020), EMA (2022))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
9948 capmatinib
Synonyms Click here for help
INC280 | INCB28060 | Tabrecta®
Database Links Click here for help
CAS Registry No. 1029712-80-8
ChEMBL Ligand CHEMBL3188267
DrugCentral Ligand 5392
GtoPdb PubChem SID 249565587
PubChem CID 25145656
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