A192621 [Ligand Id: 1009] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL332794 (A-192621)
  • ETA receptor/Endothelin receptor ET-A in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
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  • ETB receptor/Endothelin receptor ET-B in Human [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
ChEMBL Binding affinity towards human Endothelin A receptor (hET -A) B 5 pIC50 9900 nM IC50 J. Med. Chem. (1999) 42: 3668-3678 [PMID:10479298]
ChEMBL Binding affinity towards human Endothelin A receptor (hET -A) B 5.09 pIC50 8200 nM IC50 J. Med. Chem. (1999) 42: 3668-3678 [PMID:10479298]
ETB receptor/Endothelin receptor ET-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
GtoPdb - - 8.1 pKd 7.94 nM Kd J. Med. Chem. (1999) 42: 3668-78 [PMID:10479298]
ChEMBL Binding affinity towards human Endothelin B receptor (hET -B) B 7.92 pIC50 12 nM IC50 J. Med. Chem. (1999) 42: 3668-3678 [PMID:10479298]
ChEMBL Binding affinity towards human Endothelin B receptor (hET -B) B 8.19 pIC50 6.4 nM IC50 J. Med. Chem. (1999) 42: 3668-3678 [PMID:10479298]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]