ChEMBL ligand: CHEMBL3087498
DNA methyltransferase 1/DNA (cytosine-5)-methyltransferase 1 in Human [ChEMBL: CHEMBL1993] [GtoPdb: 2605] [UniProtKB: P26358] There should be some charts here, you may need to enable JavaScript!
DOT1 like histone lysine methyltransferase/Histone-lysine N-methyltransferase, H3 lysine-79 specific in Human [ChEMBL: CHEMBL1795117] [GtoPdb: 2650] [UniProtKB: Q8TEK3] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
DNA methyltransferase 1/DNA (cytosine-5)-methyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1993] [GtoPdb: 2605] [UniProtKB: P26358]
ChEMBL	Inhibition of DNMT1 (unknown origin)	B	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4518-4522 [PMID:27485386]
DOT1 like histone lysine methyltransferase/Histone-lysine N-methyltransferase, H3 lysine-79 specific in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795117] [GtoPdb: 2650] [UniProtKB: Q8TEK3]
ChEMBL	Binding affinity to DOT1L (unknown origin) by surface plasmon resonance analysis	B	10.22	pKd	0.06	nM	Kd	J Med Chem (2015) 58: 1596-1629 [PMID:25406853]
ChEMBL	Inhibition of DOT1L in human MCF10A cells assessed as reduction of H3K79 level	B	8.06	pIC50	8.8	nM	IC50	J Med Chem (2015) 58: 1596-1629 [PMID:25406853]
GtoPdb	-	-	9.52	pIC50	0.3	nM	IC50	Nat Commun (2012) 3: 1288 [PMID:23250418]
ChEMBL	Competitive inhibition of recombinant human DOT1L using adenosine/deazaadenosine as substrate and SAM cofactor	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (2013) 56: 8972-8983 [PMID:23879463]
ChEMBL	Inhibition of DOT1L (unknown origin)-mediated H3K79 methylation by cell based assay	B	8.05	pEC50	9	nM	EC50	J Med Chem (2013) 56: 8972-8983 [PMID:23879463]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]