romaciclib [Ligand Id: 13753] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4225966 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 19 in Human [GtoPdb: 1972] [UniProtKB: Q9BWU1] | ||||||||
| GtoPdb | Inhibition of CDK19/CycC kinase activity | - | 7.98 | pIC50 | 10.4 | nM | IC50 | Oncotarget (2017) 8: 33779-33795 [PMID:28422713] |
| cyclin dependent kinase 8 in Human [GtoPdb: 1980] [UniProtKB: P49336] | ||||||||
| GtoPdb | Binding dissociation constant for hCDK8 protein | - | 8.52 | pKd | 3 | nM | Kd | Oncotarget (2017) 8: 33779-33795 [PMID:28422713] |
| GtoPdb | Inhibition of CDK8/CycC kinase activity | - | 8.36 | pIC50 | 4.4 | nM | IC50 | Oncotarget (2017) 8: 33779-33795 [PMID:28422713] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
