ChEMBL ligand: CHEMBL1812661
Arginase in Plasmodium falciparum [ChEMBL: CHEMBL1795149] [UniProtKB: Q8I384] There should be some charts here, you may need to enable JavaScript!
Arginase I/Arginase-1 in Human [ChEMBL: CHEMBL1075097] [GtoPdb: 1244] [UniProtKB: P05089] Arginase I/Arginase-1 in Rat [ChEMBL: CHEMBL3232699] [GtoPdb: 1244] [UniProtKB: P07824] There should be some charts here, you may need to enable JavaScript!
Arginase II/Arginase-2, mitochondrial in Human [ChEMBL: CHEMBL1795148] [GtoPdb: 1245] [UniProtKB: P78540] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Arginase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795149] [UniProtKB: Q8I384]
ChEMBL	Binding affinity to Plasmodium falciparum arginase	B	4.96	pKd	11000	nM	Kd	J Med Chem (2011) 54: 5432-5443 [PMID:21728378]
ChEMBL	Inhibition of Plasmodium falciparum arginase using L-arginine as substrate by colorimetric assay	B	5	pKi	10000	nM	Ki	J Med Chem (2011) 54: 5432-5443 [PMID:21728378]
Arginase I/Arginase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075097] [GtoPdb: 1244] [UniProtKB: P05089]
ChEMBL	Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assay	B	7.74	pKd	18	nM	Kd	J Med Chem (2011) 54: 5432-5443 [PMID:21728378]
GtoPdb	-	-	8.3	pKd	5	nM	Kd	J Am Chem Soc (1997) 119: 8107–8108
ChEMBL	Binding affinity to human arginase 1	B	8.3	pKd	5	nM	Kd	J Med Chem (2011) 54: 5432-5443 [PMID:21728378]
ChEMBL	Binding affinity to human Arg1 at pH 8.5	B	8.3	pKd	5	nM	Kd	Bioorg Med Chem (2020) 28: 115658-115658 [PMID:32828425]
ChEMBL	Binding affinity to wild type human Arg I using L-arginine as substrate by liquid scintillation counting analysis	B	8.3	pKd	5	nM	Kd	J Med Chem (2021) 64: 17706-17727 [PMID:34875836]
ChEMBL	Inhibition of human Arginase I in human myeloid-derived suppressor cells using L-arginine as substrate assessed as L-ornithine product formation by measuring dissociation constant preincubated for 10 mins followed by ninhydrin solution and measured after 1 hrs by colorimetric assay	B	8.3	pKd	5	nM	Kd	Bioorg Med Chem Lett (2023) 84: 129193-129193 [PMID:36822300]
ChEMBL	Inhibition of recombinant human ARG1 expressed in CHO-K1 cells assessed as reduction in urea level incubated for 24 hrs by colorimetric assay	B	4.77	pIC50	16800	nM	IC50	RSC Med Chem (2020) 11: 559-568 [PMID:33479657]
ChEMBL	Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as substrate in presence of MnSO4 incubated for 60 mins by o-phthaldialdehyde/N-(1-naphthyl)ethylene-diamine dihydrochloride reagent based colorimetric assay	B	5.81	pIC50	1547	nM	IC50	J Med Chem (2019) 62: 8164-8177 [PMID:31408339]
ChEMBL	Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay	B	5.83	pIC50	1470	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4837-4841 [PMID:23886684]
ChEMBL	Inhibition of human Arg I	B	5.84	pIC50	1450	nM	IC50	J Med Chem (2021) 64: 17706-17727 [PMID:34875836]
ChEMBL	Inhibition of N-terminal hexa-histidine tagged thrombin-cleavable human arginase 1 expressed in Escherichia coli DE3 cells measured after 90 mins by colorimetric urea assay	B	5.84	pIC50	1450	nM	IC50	Bioorg Med Chem (2022) 72: 116970-116970 [PMID:36063653]
ChEMBL	Inhibition of recombinant human arginase 1 using L-arginine as substrate measured after 60 mins in presence of manganese chloride by o-phthaldialdehyde/primaquine diphosphate reagent based colorimetric assay	B	5.92	pIC50	1200	nM	IC50	ACS Med Chem Lett (2020) 11: 433-438 [PMID:32292546]
ChEMBL	Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assay	B	6.51	pIC50	311	nM	IC50	ACS Med Chem Lett (2020) 11: 582-588 [PMID:32292567]
ChEMBL	Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate addition and incubated for 60 mins by fluorescence based arginine thio ornithine generating assay	B	6.51	pIC50	311	nM	IC50	ACS Med Chem Lett (2021) 12: 1380-1388 [PMID:34527178]
ChEMBL	Binding affinity to human ARG1 assessed as dissociation constant	B	8.3	pIC50	5	nM	IC50	Eur J Med Chem (2021) 218: 113356-113356 [PMID:33773287]
Arginase I/Arginase-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232699] [GtoPdb: 1244] [UniProtKB: P07824]
ChEMBL	Inhibition of N-terminal hexa-histidine tagged thrombin-cleavable rat arginase 1 expressed in Escherichia coli DE3 cells measured after 90 mins by colorimetric urea assay	B	6.96	pKi	110	nM	Ki	Bioorg Med Chem (2022) 72: 116970-116970 [PMID:36063653]
ChEMBL	Inhibition of rat Arg1 at pH 7.4	B	6.1	pIC50	800	nM	IC50	Bioorg Med Chem (2020) 28: 115658-115658 [PMID:32828425]
ChEMBL	Inhibition of rat liver arginase using L-arginine as substrate incubated for 10 mins followed by substrate addition by scintillation counting analysis	B	6.1	pIC50	800	nM	IC50	J Med Chem (2021) 64: 17706-17727 [PMID:34875836]
ChEMBL	Inhibition of rat ARG1	B	6.1	pIC50	800	nM	IC50	Eur J Med Chem (2021) 218: 113356-113356 [PMID:33773287]
Arginase II/Arginase-2, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795148] [GtoPdb: 1245] [UniProtKB: P78540]
GtoPdb	-	-	8.07	pKi	8.5	nM	Ki	Biochemistry (2001) 40: 9356-62 [PMID:11478904]
ChEMBL	Binding affinity to human arginase 2	B	8.07	pKi	8.5	nM	Ki	J Med Chem (2011) 54: 5432-5443 [PMID:21728378]
ChEMBL	Inhibition of human Arg2 at pH 7.5	B	8.07	pKi	8.5	nM	Ki	Bioorg Med Chem (2020) 28: 115658-115658 [PMID:32828425]
ChEMBL	Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay	B	5.67	pIC50	2150	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4837-4841 [PMID:23886684]
ChEMBL	Inhibition of human Arg II	B	5.67	pIC50	2150	nM	IC50	J Med Chem (2021) 64: 17706-17727 [PMID:34875836]
ChEMBL	Binding affinity to human ARG2 assessed as inhibition constant	B	8.07	pIC50	8.5	nM	IC50	Eur J Med Chem (2021) 218: 113356-113356 [PMID:33773287]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]