telatinib

Ligand id: 10476

Name: telatinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 102.17
Molecular weight 409.09
XLogP 2.87
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-[[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methylpyridine-2-carboxamide
International Nonproprietary Names
INN number INN
8795 telatinib
Synonyms
BAY 57-9352 | Bay-57-9352 | BAY-579352 | BAY579352 | example 14 [WO2001023375A2]
Comments
Telatinib (BAY-579352) is an orally available VEGFR2/3 and PDGFRβ receptor tyrosine kinase inhibitor that exhibits potent anti-angiogenic activity which translates to anti-tumour efficacy in vitro and in vivo. The chemical structure of telatinib is claimed in Bayer's patent WO2001023375A2 (as example 14) [1].
Database Links
BindingDB Ligand 50399538
CAS Registry No. 332012-40-5 (source: WHO INN record)
ChEMBL Ligand CHEMBL2079588
GtoPdb PubChem SID 385612235
PubChem CID 9808844
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