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ChEMBL ligand: CHEMBL1371 (Chlorzoxazone, NSC-26189, Paraflex, Parafon Forte, Parafon-Forte, Parafon forte dsc, Strifon forte dsc) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
ChEMBL | Inhibitory activity against Neuronal nitric oxide synthase | B | 4.3 | pIC50 | 50000 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2887-2892 |
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] | ||||||||
ChEMBL | DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) | B | 5.55 | pIC50 | 2794 | nM | IC50 | DrugMatrix in vitro pharmacology data |
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
ChEMBL | Inhibitory activity against Endothelial nitric oxide synthase | B | 5.06 | pIC50 | 8700 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2887-2892 |
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
ChEMBL | Inhibitory activity against Inducible nitric oxide synthase | B | 4.85 | pIC50 | 14100 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2887-2892 |
KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604] | ||||||||
GtoPdb | - | - | 4.1 | pEC50 | - | - | - |
Am J Physiol, Cell Physiol (2000) 278: C570-81 [PMID:10712246]; J Pharmacol Exp Ther (2001) 296: 683-9 [PMID:11181893] |
KCa3.1 in Human [GtoPdb: 384] [UniProtKB: O15554] | ||||||||
GtoPdb | - | - | 4 | pEC50 | 100000 | nM | EC50 | Am J Physiol, Cell Physiol (2000) 278: C570-81 [PMID:10712246] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]