chlorzoxazone [Ligand Id: 2322] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1371 (Chlorzoxazone, NSC-26189, Paraflex, Parafon Forte, Parafon-Forte, Parafon forte dsc, Strifon forte dsc)
  • Neuronal NOS/Nitric-oxide synthase, brain in Human [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
  • Neuronal NOS/Nitric-oxide synthase, brain in Rat [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476]
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  • Endothelial NOS/Nitric-oxide synthase, endothelial in Human [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474]
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  • Inducible NOS/Nitric oxide synthase, inducible in Human [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
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  • KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
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  • KCa3.1 in Human [GtoPdb: 384] [UniProtKB: O15554]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
ChEMBL Inhibitory activity against Neuronal nitric oxide synthase B 4.3 pIC50 50000 nM IC50 Bioorg Med Chem Lett (1997) 7: 2887-2892
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476]
ChEMBL DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) B 5.55 pIC50 2794 nM IC50 DrugMatrix in vitro pharmacology data
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474]
ChEMBL Inhibitory activity against Endothelial nitric oxide synthase B 5.06 pIC50 8700 nM IC50 Bioorg Med Chem Lett (1997) 7: 2887-2892
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
ChEMBL Inhibitory activity against Inducible nitric oxide synthase B 4.85 pIC50 14100 nM IC50 Bioorg Med Chem Lett (1997) 7: 2887-2892
KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
GtoPdb - - 4.1 pEC50 - - - Am J Physiol, Cell Physiol (2000) 278: C570-81 [PMID:10712246];
J Pharmacol Exp Ther (2001) 296: 683-9 [PMID:11181893]
KCa3.1 in Human [GtoPdb: 384] [UniProtKB: O15554]
GtoPdb - - 4 pEC50 100000 nM EC50 Am J Physiol, Cell Physiol (2000) 278: C570-81 [PMID:10712246]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]