GnRH I [Ligand Id: 1162] activity data from GtoPdb

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  • GnRH1 receptor in Human [GtoPdb: 256] [UniProtKB: P30968]
  • GnRH1 receptor in Mouse [GtoPdb: 256] [UniProtKB: Q01776]
  • GnRH1 receptor in Rat [GtoPdb: 256] [UniProtKB: P30969]
  • 6.8
1 _lig_chart_1 GnRH1 receptor HumanMouseRat
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  • GnRH2 receptor in Monkey [GtoPdb: 257]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 GnRH2 receptor Monkey
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GnRH1 receptor in Human [GtoPdb: 256] [UniProtKB: P30968]
GtoPdb - - 8.54 pKd 2.9 nM Kd Br J Pharmacol (2016) 173: 128-41 [PMID:26398856]
GtoPdb - - 8.4 pKi 4 nM Ki Br J Pharmacol (2016) 173: 128-41 [PMID:26398856]
GtoPdb - - 8.4 pKi - - - Biochem Biophys Res Commun (2001) 289: 653-63 [PMID:11726197];
Endocrinology (2007) 148: 857-67 [PMID:17095587]
GtoPdb - - 8.6 pIC50 - - - J Biol Chem (2007) 282: 17921-9 [PMID:17452338]
GtoPdb - - 10 pEC50 0.1 nM EC50 Biosens Bioelectron (2016) 79: 721-7 [PMID:26774084]
GnRH1 receptor in Mouse [GtoPdb: 256] [UniProtKB: Q01776]
GtoPdb - - 8.3 pIC50 - - - J Biol Chem (1992) 267: 21281-4 [PMID:1328228]
GtoPdb - - 7.92 pEC50 12 nM EC50 Biosens Bioelectron (2016) 79: 721-7 [PMID:26774084]
GnRH1 receptor in Rat [GtoPdb: 256] [UniProtKB: P30969]
GtoPdb - - 6.8 pKi - - - Biochem Biophys Res Commun (2001) 289: 653-63 [PMID:11726197]
GtoPdb - - 7.7 pIC50 - - - Endocrinology (1994) 135: 315-20 [PMID:8013367]
GnRH2 receptor in Monkey [GtoPdb: 257]
GtoPdb - - 7.37 pIC50 42.6 nM IC50 Endocr Rev (2004) 25: 235-75 [PMID:15082521];
Proc Natl Acad Sci USA (2001) 98: 9636-41 [PMID:11493674]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.