GnRH<sub>2</sub> receptor | Gonadotrophin-releasing hormone receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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GnRH2 receptor

Target not currently curated in GtoImmuPdb

Target id: 257

Nomenclature: GnRH2 receptor

Family: Gonadotrophin-releasing hormone receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor: pseudogene in man
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 379 1q12 GNRHR2 gonadotropin releasing hormone receptor 2 (pseudogene)
Previous and Unofficial Names
Type II GnRHR | gonadotropin-releasing hormone (type 2) receptor 2 | gonadotropin-releasing hormone (type 2) receptor 2, pseudogene
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
Natural/Endogenous Ligands
GnRH I {Sp: Human, Mouse, Rat}
GnRH II {Sp: Human}
Comments: Probable transcribed pseudogene in man [3]. Natural/endogenous ligands refer to non-human mammalian species.
Potency order of endogenous ligands (Monkey)
GnRH II (GNRH2, O43555) > GnRH I (GNRH1, P01148)  [2]

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GnRH II {Sp: Human} Monkey Full agonist 9.0 pIC50 2
pIC50 9.0 (IC50 1.07x10-9 M) [2]
GnRH I {Sp: Human, Mouse, Rat} Monkey Full agonist 7.4 pIC50 2-3
pIC50 7.4 (IC50 4.26x10-8 M) [2-3]
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
trptorelix-1 Monkey Antagonist - - 1
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  3


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1. Maiti K, Li JH, Wang AF, Acharjee S, Kim WP, Im WB, Kwon HB, Seong JY. (2003) GnRH-II analogs for selective activation and inhibition of non-mammalian and type-II mammalian GnRH receptors. Mol. Cells, 16 (2): 173-9. [PMID:14651258]

2. Millar R, Lowe S, Conklin D, Pawson A, Maudsley S, Troskie B, Ott T, Millar M, Lincoln G, Sellar R et al.. (2001) A novel mammalian receptor for the evolutionarily conserved type II GnRH. Proc. Natl. Acad. Sci. U.S.A., 98 (17): 9636-41. [PMID:11493674]

3. Millar RP, Lu ZL, Pawson AJ, Flanagan CA, Morgan K, Maudsley SR. (2004) Gonadotropin-releasing hormone receptors. Endocr. Rev., 25 (2): 235-75. [PMID:15082521]


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