tetralin_urea analogue (7o) [Ligand Id: 1319] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL384701
  • MCH1 receptor/Melanin-concentrating hormone receptor 1 in Human [ChEMBL: CHEMBL344] [GtoPdb: 280] [UniProtKB: Q99705]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MCH1 receptor/Melanin-concentrating hormone receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL344] [GtoPdb: 280] [UniProtKB: Q99705]
ChEMBL Inhibition of 125I-MCH binding to human MCH-R1 expressed in CHO cell membranes B 8.07 pKi 8.5 nM Ki Bioorg Med Chem Lett (2007) 17: 1718-1721 [PMID:17251014]
GtoPdb - - 9.1 pKi - - - Bioorg Med Chem Lett (2007) 17: 1718-21 [PMID:17251014]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]