MC2050 [Ligand Id: 10671] activity data from GtoPdb

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  • poly(ADP-ribose) polymerase 1 in Human [GtoPdb: 2771] [UniProtKB: P09874]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 poly(ADP-ribose) polymerase 1 Human
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  • poly(ADP-ribose) polymerase 2 in Human [GtoPdb: 2772] [UniProtKB: Q9UGN5]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 poly(ADP-ribose) polymerase 2 Human
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  • tankyrase in Human [GtoPdb: 3108] [UniProtKB: O95271]
  • This target only has 0 pki data point
  • 0
3 _lig_chart_3 tankyrase Human
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  • tankyrase 2 in Human [GtoPdb: 3109] [UniProtKB: Q9H2K2]
  • This target only has 0 pki data point
  • 0
4 _lig_chart_4 tankyrase 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
poly(ADP-ribose) polymerase 1 in Human [GtoPdb: 2771] [UniProtKB: P09874]
GtoPdb inhibitory capacity of MC2050 in vitro on recombinant PARP1. - 6.92 pIC50 119 nM IC50 ChemMedChem (2011) 6: 606-11 [PMID:21365766]
GtoPdb - - 8.03 pIC50 9.3 nM IC50 ACS Med Chem Lett (2020) :
poly(ADP-ribose) polymerase 2 in Human [GtoPdb: 2772] [UniProtKB: Q9UGN5]
GtoPdb Inhibitory effect of MC2050 in vitro on recombinant PARP2. - 5.74 pIC50 1800 nM IC50 ChemMedChem (2011) 6: 606-11 [PMID:21365766]
GtoPdb - - 6.26 pIC50 549 nM IC50 ACS Med Chem Lett (2020) :
tankyrase in Human [GtoPdb: 3108] [UniProtKB: O95271]
GtoPdb - - 6.66 pIC50 218 nM IC50 ACS Med Chem Lett (2020) :
tankyrase 2 in Human [GtoPdb: 3109] [UniProtKB: Q9H2K2]
GtoPdb - - 6.71 pIC50 193 nM IC50 ACS Med Chem Lett (2020) :

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.