crizanlizumab   Click here for help

GtoPdb Ligand ID: 10550

Synonyms: Adakveo® | crizanlizumab-tmca | hSel001 [2] | SEG101
Approved drug
crizanlizumab is an approved drug (FDA (2019), EMA (2020))
Compound class: Antibody
Comment: Crizanlizumab is a humanized anti-P-selectin monoclonal that was developed by Selexys Pharmaceuticals (and later acquired by Novartis) as a preventative therapy for sickle cell crises [1]. The antibody and its use are claimed in Selexys' patent WO2012088265A1 [2]. Crizanlizumab was designed to limit complement activation. In clinical trial no anti-crizanlizumab antibodies could be detected [1].
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Classification Click here for help
Compound class Antibody
Approved drug? Yes (FDA (2019), EMA (2020))
International Nonproprietary Names Click here for help
INN number INN
10316 crizanlizumab
Synonyms Click here for help
Adakveo® | crizanlizumab-tmca | hSel001 [2] | SEG101
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 667
Other databases
GtoPdb PubChem SID 404858999
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