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ChEMBL ligand: CHEMBL414157 (BG-9928, BG9928, Tonapofylline) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
GtoPdb | - | - | 8.13 | pKi | 7.4 | nM | Ki | J Med Chem (2006) 49: 7119-31 [PMID:17125264] |
ChEMBL | Binding affinity to human adenosine A1 receptor | B | 8.13 | pKi | 7.4 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
ChEMBL | Displacement of [125I]ABA from human adenosine A1 receptor | B | 8.15 | pKi | 7 | nM | Ki | J Med Chem (2006) 49: 7132-7139 [PMID:17125265] |
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
ChEMBL | Intrinsic activity at adenosine A1 receptor assessed as blockade of CPA in isolated spontaneously beating rat atria | F | 9.8 | pKd | 0.16 | nM | Kd | J Med Chem (2006) 49: 7132-7139 [PMID:17125265] |
ChEMBL | Binding affinity to rat adenosine A1 receptor | B | 8.89 | pKi | 1.3 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
GtoPdb | - | - | 8.89 | pKi | 1.3 | nM | Ki | J Med Chem (2006) 49: 7119-31 [PMID:17125264] |
ChEMBL | Displacement of [3H]DPCPX from adenosine A1 receptor in rat cerebral cortex | B | 9 | pKi | 1 | nM | Ki | J Med Chem (2006) 49: 7132-7139 [PMID:17125265] |
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
GtoPdb | - | - | 5.19 | pKi | 6410 | nM | Ki | J Med Chem (2006) 49: 7119-31 [PMID:17125264] |
ChEMBL | Binding affinity to human adenosine A2A receptor | B | 5.19 | pKi | 6410 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
ChEMBL | Displacement of [125I]ZM-241385 from human adenosine A2A receptor | B | 5.19 | pKi | 6400 | nM | Ki | J Med Chem (2006) 49: 7132-7139 [PMID:17125265] |
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
GtoPdb | - | - | 5.61 | pKi | 2440 | nM | Ki | J Med Chem (2006) 49: 7119-31 [PMID:17125264] |
ChEMBL | Binding affinity to rat adenosine A2A receptor | B | 5.61 | pKi | 2440 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
ChEMBL | Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor | B | 7.05 | pKi | 90 | nM | Ki | J Med Chem (2006) 49: 7132-7139 [PMID:17125265] |
ChEMBL | Binding affinity to human adenosine A2B receptor | B | 7.05 | pKi | 90 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
GtoPdb | - | - | 7.05 | pKi | 90 | nM | Ki | J Med Chem (2006) 49: 7119-31 [PMID:17125264] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
GtoPdb | - | - | 5 | pKi | >10000 | nM | Ki | J Med Chem (2006) 49: 7119-31 [PMID:17125264] |
ChEMBL | Displacement of [125I]ABA from human adenosine A3 receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2006) 49: 7132-7139 [PMID:17125265] |
ChEMBL | Binding affinity to human adenosine A3 receptor | B | 5 | pKi | 10000 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]