fexaramine [Ligand Id: 2744] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL192966 (Fexaramine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Farnesoid X receptor/Bile acid receptor FXR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1] | ||||||||
| GtoPdb | - | - | 6.6 | pEC50 | - | - | - | Mol Cell (2003) 11: 1079-92 [PMID:12718892] |
| ChEMBL | Effective concentration against farnesoid X receptor (FXR) | B | 7.6 | pEC50 | 25 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3119-3125 [PMID:15893927] |
| ChEMBL | Effective concentration against farnesoid X receptor (FXR) | B | 7.6 | pEC50 | 25 | nM | EC50 | J Med Chem (2005) 48: 5613-5638 [PMID:16134928] |
| ChEMBL | Effective concentration towards farnesoid X receptor (FXR) | B | 7.6 | pEC50 | 25 | nM | EC50 | J Med Chem (2005) 48: 5613-5638 [PMID:16134928] |
| ChEMBL | Agonist activity at FXR | F | 7.6 | pEC50 | 25 | nM | EC50 | Nat Chem Biol (2005) 1: 74-84 [PMID:16408003] |
| ChEMBL | Agonist activity at FXR | F | 7.6 | pEC50 | 25 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6848-6853 [PMID:23040732] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
