Rec 15/2615 [Ligand Id: 8459] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL430717 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
| ChEMBL | The binding affinity towards Alpha-1C adrenergic receptor in the COS cell line. | B | 7.99 | pKi | 10.34 | nM | Ki | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
| Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130] | ||||||||
| ChEMBL | Binding affinity was tested on cloned bovine Alpha-1A adrenergic receptor | B | 7.76 | pIC50 | 17.2 | nM | IC50 | J Med Chem (1997) 40: 1293-1315 [PMID:9135028] |
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] | ||||||||
| ChEMBL | The binding affinity towards Alpha-1A adrenergic receptor in the COS cell line. | B | 8.12 | pKi | 7.5 | nM | Ki | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
| ChEMBL | The binding affinity towards Alpha-1B adrenergic receptor in the COS cell line. | B | 9.35 | pKi | 0.45 | nM | Ki | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
| GtoPdb | - | - | 9.5 | pKi | - | - | - |
J Pharmacol Exp Ther (1997) 281: 1284-93 [PMID:9190864]; Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144] |
| ChEMBL | Binding affinity was tested on cloned hamster Alpha-1B adrenergic receptor | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1997) 40: 1293-1315 [PMID:9135028] |
| α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944] | ||||||||
| ChEMBL | Binding affinity was tested on cloned rat Alpha-1D adrenergic receptor | B | 7.64 | pIC50 | 22.9 | nM | IC50 | J Med Chem (1997) 40: 1293-1315 [PMID:9135028] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Inhibitory concentration against Dopamine receptor D2 (Inactive at >1000 nM concentration) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Inhibitory concentration against 5-hydroxytryptamine 1A receptor (Inactive at >1000 nM concentration) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| ChEMBL | Inhibitory concentration against 5-hydroxytryptamine 2A receptor (Inactive at >1000 nM concentration) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
