RO3 [Ligand Id: 4298] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL494772 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| P2X3/P2X2/P2X2/P2X3 heterotrimeric receptor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3831281] [GtoPdb: 480, 479] [UniProtKB: P56373, Q9UBL9] | ||||||||
| ChEMBL | Antagonist activity at human recombinant P2X2/3 receptor expressed in human 1321N1 cells by FLIPR assay | F | 5.7 | pIC50 | 1995.26 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1628-1631 [PMID:19231180] |
| GtoPdb | - | - | 7.5 | pIC50 | ~31 | nM | IC50 | Br J Pharmacol (2006) 147 Suppl 2: S132-43 [PMID:16465177] |
| P2X3 in Human [GtoPdb: 480] [UniProtKB: P56373] | ||||||||
| GtoPdb | - | - | 7.5 | pIC50 | ~31 | nM | IC50 | Br J Pharmacol (2006) 147 Suppl 2: S132-43 [PMID:16465177] |
| P2X3/P2X purinoceptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4824] [GtoPdb: 480] [UniProtKB: P49654] | ||||||||
| ChEMBL | Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assay | F | 6.9 | pIC50 | 125.89 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1628-1631 [PMID:19231180] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
