ADL5859 [Ligand Id: 9004] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL494480 (Adl-5859)
  • δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
There should be some charts here, you may need to enable JavaScript!
  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cells B 9.08 pKi 0.84 nM Ki J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
GtoPdb - - 9.08 pKi 0.84 nM Ki J Med Chem (2008) 51: 5893-6 [PMID:18788723]
ChEMBL Agonist activity at human delta opioid receptor in CHO cells assessed as stimulation of [35S]GTPgammaS binding F 7.7 pEC50 20 nM EC50 J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG channel in HEK293 cells by voltage-clamp method B 4.11 pIC50 78000 nM IC50 J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb - - 7.43 pKi 37 nM Ki J Med Chem (2008) 51: 5893-6 [PMID:18788723]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 7.49 pKi 32 nM Ki J Med Chem (2008) 51: 5893-6 [PMID:18788723]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]