clofibrate [Ligand Id: 2667] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL565 (Atromid, Atromid-s, AY-61123, Chlorfenisate, Clofibrate, Ethyl p-chlorophenoxyisobutyrate, ICI 28257, ICI-28257, NSC-79389) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692] | ||||||||
| ChEMBL | Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 42 deg C by fluorimetric assay | B | 4.92 | pKd | 12000 | nM | Kd | J Med Chem (2009) 52: 5344-5355 [PMID:19663428] |
| ChEMBL | Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 37 deg C by fluorimetric assay | B | 4.96 | pKd | 11000 | nM | Kd | J Med Chem (2009) 52: 5344-5355 [PMID:19663428] |
| ChEMBL | Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 30 deg C by fluorimetric assay | B | 5.02 | pKd | 9600 | nM | Kd | J Med Chem (2009) 52: 5344-5355 [PMID:19663428] |
| ChEMBL | Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 25 deg C by fluorimetric assay | B | 5.05 | pKd | 8900 | nM | Kd | J Med Chem (2009) 52: 5344-5355 [PMID:19663428] |
| ChEMBL | Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 20 deg C by fluorimetric assay | B | 5.11 | pKd | 7800 | nM | Kd | J Med Chem (2009) 52: 5344-5355 [PMID:19663428] |
| ChEMBL | Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 15 deg C by fluorimetric assay | B | 5.14 | pKd | 7300 | nM | Kd | J Med Chem (2009) 52: 5344-5355 [PMID:19663428] |
| ChEMBL | Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 10 deg C by fluorimetric assay | B | 5.17 | pKd | 6700 | nM | Kd | J Med Chem (2009) 52: 5344-5355 [PMID:19663428] |
| ChEMBL | Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 5 deg C by fluorimetric assay | B | 5.22 | pKd | 6000 | nM | Kd | J Med Chem (2009) 52: 5344-5355 [PMID:19663428] |
| ChEMBL | Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay | B | 5.16 | pKi | 6920 | nM | Ki | J Med Chem (2008) 51: 3755-3764 [PMID:18533710] |
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| GtoPdb | - | - | 4.25 | pIC50 | - | - | - |
J Med Chem (1998) 41: 5020-36 [PMID:9836620]; J Med Chem (2004) 47: 4118-27 [PMID:15293980]; J Med Chem (2000) 43: 527-50 [PMID:10691680] |
| ChEMBL | Agonist activity for Human PPAR alpha receptor in transcriptional activation assay | F | 4.26 | pEC50 | 55000 | nM | EC50 | J Med Chem (2000) 43: 527-550 [PMID:10691680] |
| ChEMBL | Effective concentration against human peroxisome proliferator activated receptor alpha in Gal4 transactivation assay | B | 4.26 | pEC50 | 55000 | nM | EC50 | J Med Chem (2004) 47: 4118-4127 [PMID:15293980] |
| ChEMBL | Agonist activity at PPARalpha | F | 4.26 | pEC50 | 55000 | nM | EC50 | J Med Chem (2012) 55: 4027-4061 [PMID:22260081] |
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2128] [GtoPdb: 593] [UniProtKB: P23204] | ||||||||
| ChEMBL | Agonist activity for murine PPAR alpha receptor in transcriptional activation assay | F | 4.3 | pEC50 | 50000 | nM | EC50 | J Med Chem (2000) 43: 527-550 [PMID:10691680] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
