GNF-5837 [Ligand Id: 8071] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2037226 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b ALK | B | 5.17 | pIC50 | 6800 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b ALK | B | 5.47 | pIC50 | 3400 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5771] [GtoPdb: 1839] [UniProtKB: P97793] | ||||||||
| ChEMBL | Inhibition of Tel-fused ALK in mouse BA/F3 cells | B | 5.47 | pIC50 | 3400 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| BMX non-receptor tyrosine kinase/Cytoplasmic tyrosine-protein kinase BMX in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034793] [GtoPdb: 1942] [UniProtKB: P97504] | ||||||||
| ChEMBL | Inhibition of Tel-fused BMX in mouse BA/F3 cells | B | 5.17 | pIC50 | 6700 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| EPH receptor A3/Ephrin type-A receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b EPHA3 | B | 5.23 | pIC50 | 5900 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| EPH receptor A3/Ephrin type-A receptor 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034794] [GtoPdb: 1823] [UniProtKB: P29319] | ||||||||
| ChEMBL | Inhibition of Tel-fused EPHA3 in mouse BA/F3 cells | B | 5.23 | pIC50 | 5900 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b EPHB2 | B | 5.24 | pIC50 | 5800 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| EPH receptor B2/Ephrin type-B receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5961] [GtoPdb: 1831] [UniProtKB: P54763] | ||||||||
| ChEMBL | Inhibition of Tel-fused EPHB2 in mouse BA/F3 cells | B | 5.24 | pIC50 | 5800 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b FGFR3 | B | 5.03 | pIC50 | 9300 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4066] [GtoPdb: 1810] [UniProtKB: Q61851] | ||||||||
| ChEMBL | Inhibition of Tel-fused FGFR3 in mouse BA/F3 cells | B | 5.03 | pIC50 | 9300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b FGFR4 | B | 5.15 | pIC50 | 7000 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3839] [GtoPdb: 1811] [UniProtKB: Q03142] | ||||||||
| ChEMBL | Inhibition of Tel-fused FGFR4 in mouse BA/F3 cells | B | 5.15 | pIC50 | 7000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b MET | B | 5.24 | pIC50 | 5800 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5585] [GtoPdb: 1815] [UniProtKB: P16056] | ||||||||
| ChEMBL | Inhibition of Tel-fused MET in mouse BA/F3 cells | B | 5.24 | pIC50 | 5800 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| Insulin-like growth factor I receptor/Insulin-like growth factor 1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5381] [GtoPdb: 1801] [UniProtKB: Q60751] | ||||||||
| ChEMBL | Inhibition of Tel-fused IGF1R in mouse BA/F3 cells | B | 5.12 | pIC50 | 7600 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b IGF1R | B | 5.12 | pIC50 | 7600 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b INSR | B | 5.1 | pIC50 | 8000 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| Insulin receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3187] [GtoPdb: 1800] [UniProtKB: P15208] | ||||||||
| ChEMBL | Inhibition of Tel-fused INSR in mouse BA/F3 cells | B | 5.1 | pIC50 | 8000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| colony stimulating factor 1 receptor/Macrophage colony-stimulating factor 1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5570] [GtoPdb: 1806] [UniProtKB: P09581] | ||||||||
| ChEMBL | Inhibition of Tel-fused FMS in mouse BA/F3 cells | B | 5.4 | pIC50 | 4000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b CSF1R | B | 5.4 | pIC50 | 4000 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b MST1R | B | 5.33 | pIC50 | 4700 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795170] [GtoPdb: 1816] [UniProtKB: Q62190] | ||||||||
| ChEMBL | Inhibition of Tel-fused RON in mouse BA/F3 cells | B | 5.33 | pIC50 | 4700 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| KIT proto-oncogene, receptor tyrosine kinase/Mast/stem cell growth factor receptor Kit in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034798] [GtoPdb: 1805] [UniProtKB: P05532] | ||||||||
| ChEMBL | Inhibition of Tel-fused KIT in mouse BA/F3 cells | B | 6.04 | pIC50 | 910 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| mitogen-activated protein kinase 9/Mitogen-activated protein kinase 9 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034797] [GtoPdb: 1497] [UniProtKB: Q9WTU6] | ||||||||
| ChEMBL | Inhibition of Tel-fused JNK2 in mouse BA/F3 cells | B | 5.54 | pIC50 | 2900 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
| ChEMBL | Inhibition of N-terminal GST-tagged human recombinant TRKA G595R mutant (440 to end residues) expressed in baculovirus infected Sf9 insect cells incubated for 30 mins in presence of ATP by HTRF assay | B | 6.49 | pIC50 | 320 | nM | IC50 | Eur J Med Chem (2023) 253: 115291-115291 [PMID:37030091] |
| ChEMBL | Inhibition of N-terminal GST-tagged human recombinant TRKA G667C mutant (440 to end residues) expressed in baculovirus infected Sf9 insect cells incubated for 30 mins in presence of ATP by HTRF assay | B | 7.35 | pIC50 | 45 | nM | IC50 | Eur J Med Chem (2023) 253: 115291-115291 [PMID:37030091] |
| ChEMBL | Affinity On-target Cellular interaction: (Proliferation assay (in Ba/F3 cells expressing activated NTRK1, Tel-TRK or Tel-KDR fusions)) EUB0000136b NTRK1 | B | 7.96 | pIC50 | 11 | nM | IC50 | Affinity On-target Cellular Literature for EUbOPEN Chemogenomic Library |
| GtoPdb | - | - | 7.96 | pIC50 | 11 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-5 [PMID:24900443] |
| ChEMBL | Inhibition of TRKA by HTRF assay | B | 8.1 | pIC50 | 8 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| ChEMBL | Affinity Biochemical interaction: (HTRF assay) EUB0000136b NTRK1 | B | 8.1 | pIC50 | 8 | nM | IC50 | Affinity Biochemical Literature for EUbOPEN Chemogenomic Library |
| neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
| ChEMBL | Inhibition of TRKB by HTRF assay | B | 7.92 | pIC50 | 12 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| ChEMBL | Affinity Biochemical interaction: (Caliper microfluidic assay) EUB0000136b NTRK2 | B | 7.92 | pIC50 | 12 | nM | IC50 | Affinity Biochemical Literature for EUbOPEN Chemogenomic Library |
| ChEMBL | Affinity On-target Cellular interaction: (Proliferation assay (in Ba/F3 cells expressing activated NTRK2, Tel-TRK or Tel-KDR fusions)) EUB0000136b NTRK2 | B | 8.05 | pIC50 | 9 | nM | IC50 | Affinity On-target Cellular Literature for EUbOPEN Chemogenomic Library |
| GtoPdb | - | - | 8.05 | pIC50 | 9 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-5 [PMID:24900443] |
| neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-5 [PMID:24900443] |
| ChEMBL | Affinity On-target Cellular interaction: (Proliferation assay (in Ba/F3 cells expressing activated NTRK3, Tel-TRK or Tel-KDR fusions)) EUB0000136b NTRK3 | B | 8.15 | pIC50 | 7 | nM | IC50 | Affinity On-target Cellular Literature for EUbOPEN Chemogenomic Library |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b PDGFRB | B | 6.06 | pIC50 | 870 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2749] [GtoPdb: 1804] [UniProtKB: P05622] | ||||||||
| ChEMBL | Inhibition of Tel-fused PDGFRbeta in mouse BA/F3 cells | B | 6.06 | pIC50 | 870 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| ret proto-oncogene/Proto-oncogene tyrosine-protein kinase receptor Ret in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034799] [GtoPdb: 2185] [UniProtKB: P35546] | ||||||||
| ChEMBL | Inhibition of Tel-fused RET in mouse BA/F3 cells | B | 5.28 | pIC50 | 5300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b ROS1 | B | 5.22 | pIC50 | 6000 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034802] [GtoPdb: 1840] [UniProtKB: Q78DX7] | ||||||||
| ChEMBL | Inhibition of Tel-fused ROS in mouse BA/F3 cells | B | 5.22 | pIC50 | 6000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| fms related receptor tyrosine kinase 3/Receptor-type tyrosine-protein kinase FLT3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034796] [GtoPdb: 1807] [UniProtKB: Q00342] | ||||||||
| ChEMBL | Inhibition of Tel-fused FLT3 in mouse BA/F3 cells | B | 5.29 | pIC50 | 5100 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Inhibition of c-Kit in human Mo7e cells | B | 6 | pIC50 | 1000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b KIT | B | 6.04 | pIC50 | 910 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b ABL1 | B | 5.09 | pIC50 | 8200 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| BMX non-receptor tyrosine kinase/Tyrosine-protein kinase BMX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3834] [GtoPdb: 1942] [UniProtKB: P51813] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b BMX | B | 5.17 | pIC50 | 6700 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b FGR | B | 5.44 | pIC50 | 3600 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fgr in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034795] [GtoPdb: 2024] [UniProtKB: P14234] | ||||||||
| ChEMBL | Inhibition of Tel-fused FGR in mouse BA/F3 cells | B | 5.44 | pIC50 | 3600 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b JAK2 | B | 5.54 | pIC50 | 2900 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b LYN | B | 5.14 | pIC50 | 7300 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2258] [GtoPdb: 2060] [UniProtKB: P25911] | ||||||||
| ChEMBL | Inhibition of Tel-fused LYN in mouse BA/F3 cells | B | 5.14 | pIC50 | 7300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b FLT3 | B | 5.29 | pIC50 | 5100 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b RET | B | 5.28 | pIC50 | 5300 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5274] [GtoPdb: 1841] [UniProtKB: P35590] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b TIE1 | B | 5.24 | pIC50 | 5700 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034800] [GtoPdb: 1841] [UniProtKB: Q06806] | ||||||||
| ChEMBL | Inhibition of Tel-fused TIE1 in mouse BA/F3 cells | B | 5.24 | pIC50 | 5700 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b SRC | B | 5.14 | pIC50 | 7300 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3074] [GtoPdb: 2206] [UniProtKB: P05480] | ||||||||
| ChEMBL | Inhibition of Tel-fused SRC in mouse BA/F3 cells | B | 5.14 | pIC50 | 7300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b ZAP70 | B | 5.33 | pIC50 | 4700 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034801] [GtoPdb: 2285] [UniProtKB: P43404] | ||||||||
| ChEMBL | Inhibition of Tel-fused ZAP70 in mouse BA/F3 cells | B | 5.33 | pIC50 | 4700 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
| fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
| ChEMBL | Selectivity interaction (Cellular Kinase Panel (Ba/F3 cells fused with a Tel dimerization partner)) EUB0000136b FLT1 | B | 5.36 | pIC50 | 4400 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomic Library |
| fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3516] [GtoPdb: 1812] [UniProtKB: P35969] | ||||||||
| ChEMBL | Inhibition of Tel-fused FLT1 in mouse BA/F3 cells | B | 5.36 | pIC50 | 4400 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
