all-trans-retinal [Ligand Id: 2350] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL81379 (All-Trans-Retinal, Retinal)
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  • CNGA2 in Rat [GtoPdb: 395] [UniProtKB: Q00195]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840]
ChEMBL Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay B 6.72 pIC50 190 nM IC50 Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Inhibition of amyloid beta (1 to 40) (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay B 6.74 pIC50 180 nM IC50 Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
CNGA2 in Rat [GtoPdb: 395] [UniProtKB: Q00195]
GtoPdb - - 4.57 pIC50 - - - Proc Natl Acad Sci USA (2002) 99: 8372-7 [PMID:12034887]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]