ChEMBL ligand: CHEMBL4098877 (Merck lrrk2 inhibitor-2)
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1] There should be some charts here, you may need to enable JavaScript!
TTK protein kinase/Dual specificity protein kinase TTK in Human [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] There should be some charts here, you may need to enable JavaScript!
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase kinase 14/Mitogen-activated protein kinase kinase kinase 14 in Human [ChEMBL: CHEMBL5888] [GtoPdb: 2074] [UniProtKB: Q99558] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683] There should be some charts here, you may need to enable JavaScript!
σ2/Sigma intracellular receptor 2 in Human [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
ChEMBL	CLK2 Kinase screen	B	6.22	pIC50	605	nM	IC50	Data for DCP probe MLi-2
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
ChEMBL	CLK4 Kinase screen	B	6.65	pIC50	225	nM	IC50	Data for DCP probe MLi-2
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
ChEMBL	TTK Kinase screen	B	6.03	pIC50	935	nM	IC50	Data for DCP probe MLi-2
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
GtoPdb	Determined in a biochemical assay at physiologically relevant ATP concentration (5mM) to mimic cellular conditions.	-	8.19	pIC50	6.4	nM	IC50	J Med Chem (2017) 60: 2983-2992 [PMID:28245354]
ChEMBL	Inhibition of recombinant human GST-tagged LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus using fluorescein-ERM as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr in presence of 5 mM ATP by TR-FRET assay	B	8.19	pIC50	6.4	nM	IC50	J Med Chem (2017) 60: 2983-2992 [PMID:28245354]
ChEMBL	LRRK2 Biochemical Assay with 5mM ATP	B	8.2	pIC50	6.3	nM	IC50	Data for DCP probe MLi-2
ChEMBL	Inhibition LRRK2 G2019S mutant Ser935 phosphorylation in human SH-SY5Y cells after 90 mins by Western blot analysis	B	8.32	pIC50	4.8	nM	IC50	J Med Chem (2017) 60: 2983-2992 [PMID:28245354]
ChEMBL	Cellular assay monitoring dephosphorylation of pSer935 LRRK2	B	8.46	pIC50	3.5	nM	IC50	Data for DCP probe MLi-2
ChEMBL	LRRK2 Biochemical Assay	B	8.74	pIC50	1.8	nM	IC50	Data for DCP probe MLi-2
ChEMBL	Inhibition of recombinant human GST-tagged LRRK2 G2019S mutant catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr by LanthaScreen assay	B	9.1	pIC50	0.8	nM	IC50	J Med Chem (2020) 63: 11330-11361 [PMID:32352776]
ChEMBL	Inhibition of recombinant human GST-tagged LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus using fluorescein-ERM as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by TR-FRET assay	B	9.12	pIC50	0.76	nM	IC50	J Med Chem (2017) 60: 2983-2992 [PMID:28245354]
ChEMBL	NanoBRET (SGC Frankfurt)	B	8.91	pEC50	1.22	nM	EC50	Data for DCP probe MLi-2
mitogen-activated protein kinase kinase kinase 14/Mitogen-activated protein kinase kinase kinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5888] [GtoPdb: 2074] [UniProtKB: Q99558]
ChEMBL	MAP3K14 (NIK) Kinase screen	B	6.61	pIC50	244	nM	IC50	Data for DCP probe MLi-2
mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
ChEMBL	MAP3K5 (ASK1) Kinase screen	B	6.37	pIC50	428	nM	IC50	Data for DCP probe MLi-2
σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2]
ChEMBL	GPCRScan assay: inhibition of Sigma 2	B	5.34	pKi	4600.45	nM	Ki	Data for DCP probe MLi-2
ChEMBL	GPCRScan assay: inhibition of Sigma 2	B	5.34	pKi	4570.88	nM	Ki	Data for DCP probe MLi-2

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]