muraymycin D2 [Ligand Id: 13501] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1780216 ((-)-Muramycin 2D, Muramycin D2, Muraymycin D2) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Phospho-N-acetylmuramoyl-pentapeptide-transferase in Bacillus subtilis (strain 168) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075151] [UniProtKB: Q03521] | ||||||||
| ChEMBL | Competitive inhibition of Bacillus subtilis MraY using UDP-MurNAc-pentapeptide as substrate after 30 mins by Lineweaver-Burk plot | B | 8.12 | pKi | 7.6 | nM | Ki | J Med Chem (2011) 54: 8421-8439 [PMID:22085339] |
| ChEMBL | Noncompetitive inhibition of Bacillus subtilis MraY using radiolabeled UDP-GlcNAc as substrate after 30 mins by Lineweaver-Burk plot | B | 8.12 | pKi | 7.6 | nM | Ki | J Med Chem (2011) 54: 8421-8439 [PMID:22085339] |
| ChEMBL | Inhibition of purified Bacillus subtilis MraY assessed as incorporation of MurNAc-[14C]pentapeptide into lipid 1 after 30 mins | B | 8 | pIC50 | 10 | nM | IC50 | ACS Med Chem Lett (2010) 1: 258-262 [PMID:24900205] |
| ChEMBL | Inhibition of Bacillus subtilis MraY using radiolabeled UDP-MurNAc-[14C]pentapeptide as substrate after 30 mins | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2011) 54: 8421-8439 [PMID:22085339] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
