WZ4002 [Ligand Id: 9176] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1229592 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
| ChEMBL | Inhibition of GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay | B | 6 | pIC50 | 990 | nM | IC50 | Eur J Med Chem (2017) 136: 497-510 [PMID:28528303] |
| cathepsin C/Dipeptidyl peptidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2252] [GtoPdb: 2344] [UniProtKB: P53634] | ||||||||
| ChEMBL | Inhibition of CatL-activated recombinant human C-terminal His10-tagged cathepsin C (25 to 463 residues) expressed in mouse myeloma cells using Gly-Phe-AFC as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2019) 62: 5901-5919 [PMID:31145622] |
| ChEMBL | Inhibition of cathepsin C (unknown origin) | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2019) 62: 5901-5919 [PMID:31145622] |
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Binding affinity to recombinant EGFR L858R/T90M mutant | B | 6.89 | pKd | 130 | nM | Kd | J Med Chem (2012) 55: 6243-6262 [PMID:22621397] |
| ChEMBL | Binding affinity to EGFR | B | 7.34 | pKd | 46 | nM | Kd | J Med Chem (2012) 55: 2711-2723 [PMID:22339342] |
| GtoPdb | - | - | 7.34 | pKd | 46 | nM | Kd | Nature (2009) 462: 1070-4 [PMID:20033049] |
| ChEMBL | Binding affinity to EGFR L858R mutant | B | 7.54 | pKd | 29 | nM | Kd | J Med Chem (2012) 55: 2711-2723 [PMID:22339342] |
| ChEMBL | Binding affinity to partial length human EGFR L858R/T790M double mutant expressed in mammalian system by KINOMEscan assay | B | 9.52 | pKd | 0.3 | nM | Kd | J Med Chem (2016) 59: 6580-6594 [PMID:26882288] |
| ChEMBL | Inhibition of EGFR in human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay | B | 4.74 | pIC50 | 18210 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 4832-4837 [PMID:28974338] |
| ChEMBL | Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assay | B | 5.07 | pIC50 | 8600 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 4832-4837 [PMID:28974338] |
| ChEMBL | Inhibition of recombinant human N-terminally GST-tagged EGFR L858R/T790M/C797S triple mutant expressed in baculovirus in Sf9 insect cells preincubated for 20 mins followed by addition of [33P]-ATP measured after 2 hrs by filter-binding method | B | 5.69 | pIC50 | 2050 | nM | IC50 | J Med Chem (2017) 60: 4636-4656 [PMID:28482151] |
| ChEMBL | Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assay | B | 5.93 | pIC50 | 1180 | nM | IC50 | J Med Chem (2013) 56: 7025-7048 [PMID:23930994] |
| ChEMBL | Inhibition of wild-type EGFR phosphorylation in human A431 cells preincubated for 1 hr followed by EGF stimulation measured after 45 mins by ELISA | B | 6.15 | pIC50 | 710 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1257-1261 [PMID:29534926] |
| ChEMBL | Inhibition of wild type GST-tagged human EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay | B | 6.92 | pIC50 | 120 | nM | IC50 | Eur J Med Chem (2017) 136: 497-510 [PMID:28528303] |
| ChEMBL | Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assay | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 4832-4837 [PMID:28974338] |
| ChEMBL | Inhibition of wild type recombinant human EGFR preincubated for 10 mins followed by FAM-labeled peptide/ATP addition measured after 1 hr by mobility shift assay | B | 7.1 | pIC50 | 79 | nM | IC50 | Eur J Med Chem (2015) 104: 115-126 [PMID:26451770] |
| ChEMBL | Inhibition of EGFR L858R/T790M mutant phosphorylation in human NCI-H1975 cells after 1 hr by ELISA | B | 7.34 | pIC50 | 46 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1257-1261 [PMID:29534926] |
| ChEMBL | Inhibition of wild-type EGFR (unknown origin) expressed in baculovirus expression system after 1 hr by ELISA | B | 7.51 | pIC50 | 31.1 | nM | IC50 | Bioorg Med Chem (2016) 24: 2673-2680 [PMID:27131639] |
| ChEMBL | Inhibition of human recombinant EGFR T790M/L858R double mutant preincubated for 10 mins followed by FAM-labeled peptide/ATP addition measured after 1 hr by mobility shift assay | B | 7.51 | pIC50 | 31 | nM | IC50 | Eur J Med Chem (2015) 104: 115-126 [PMID:26451770] |
| ChEMBL | Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assay | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (2013) 56: 7025-7048 [PMID:23930994] |
| ChEMBL | Inhibition of recombinant human GST-tagged wild-type EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay | B | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1257-1261 [PMID:29534926] |
| ChEMBL | Inhibition of wild type N-terminal His6-tagged human EGFR kinase domain (702 to 1016 residues) expressed in Sf9 cells pre-incubated for 30 mins before ATP and substrate addition by homogeneous time-resolved FRET assay | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem (2015) 23: 2767-2780 [PMID:25975640] |
| ChEMBL | Inhibition of wild type EGFR (unknown origin) expressed in Sf9 cells pre-incubated for 30 mins before substrate and ATP addition by homogeneous time-resolved FRET assay | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2015) 58: 6844-6863 [PMID:26275028] |
| ChEMBL | Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISA | B | 8.01 | pIC50 | 9.7 | nM | IC50 | Bioorg Med Chem (2016) 24: 2673-2680 [PMID:27131639] |
| ChEMBL | Inhibition of EGFR kinase L858R mutant (unknown origin) after 1.5 hrs by FRET-based Z'-Lyte assay | B | 8.09 | pIC50 | 8.13 | nM | IC50 | Medchemcomm (2012) 3: 1155-1159 |
| ChEMBL | Inhibition of wild type EGFR kinase (unknown origin) after 1.5 hrs by FRET-based Z'-Lyte assay | B | 8.19 | pIC50 | 6.47 | nM | IC50 | Medchemcomm (2012) 3: 1155-1159 |
| ChEMBL | Inhibition of EGFR L858R/T790M mutant (unknown origin) using Poly(Glu,Tyr)4:1 as substrate incubated for 1 hr by ELISA | B | 8.19 | pIC50 | 6.4 | nM | IC50 | Medchemcomm (2015) 6: 1693-1697 |
| ChEMBL | Inhibition of EGFR after 1.5 hr by FRET assay | B | 8.21 | pIC50 | 6.18 | nM | IC50 | J Med Chem (2012) 55: 2711-2723 [PMID:22339342] |
| ChEMBL | Inhibition of EGFR L861Q mutant after 1.5 hr by FRET assay | B | 8.21 | pIC50 | 6.13 | nM | IC50 | J Med Chem (2012) 55: 2711-2723 [PMID:22339342] |
| ChEMBL | Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET based Z'-lyte assay | B | 8.27 | pIC50 | 5.4 | nM | IC50 | Eur J Med Chem (2013) 66: 82-90 [PMID:23792318] |
| ChEMBL | Inhibition of EGFR L858R mutant (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assay | B | 8.27 | pIC50 | 5.4 | nM | IC50 | J Med Chem (2013) 56: 4738-4748 [PMID:23668441] |
| ChEMBL | Inhibition of EGFR L858R mutant after 1.5 hr by FRET assay | B | 8.27 | pIC50 | 5.37 | nM | IC50 | J Med Chem (2012) 55: 2711-2723 [PMID:22339342] |
| ChEMBL | Inhibition of GST-tagged human EGFR T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay | B | 8.3 | pIC50 | 5 | nM | IC50 | Eur J Med Chem (2017) 136: 497-510 [PMID:28528303] |
| ChEMBL | Inhibition of EGFR L858R mutant (unknown origin) after 1.5 hr by FRET-based Z-lyte assay | B | 8.32 | pIC50 | 4.8 | nM | IC50 | Eur J Med Chem (2014) 77: 75-83 [PMID:24607591] |
| ChEMBL | Inhibition of N-terminal GST-tagged human recombinant EGFR L858R mutant (668 to 1210 residues) expressed in baculovirus expression system by Z'-LYTE kinase assay | B | 8.33 | pIC50 | 4.64 | nM | IC50 | Eur J Med Chem (2021) 211: 113022-113022 [PMID:33239261] |
| ChEMBL | Inhibition of N-terminal GST-tagged human recombinant EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system by Z'-LYTE kinase assay | B | 8.34 | pIC50 | 4.59 | nM | IC50 | Eur J Med Chem (2021) 211: 113022-113022 [PMID:33239261] |
| ChEMBL | Inhibition of EGFR (unknown origin) after 1.5 hr by FRET-based Z-lyte assay | B | 8.36 | pIC50 | 4.4 | nM | IC50 | Eur J Med Chem (2014) 77: 75-83 [PMID:24607591] |
| ChEMBL | Inhibition of EGFR kinase L861Q mutant (unknown origin) after 1.5 hrs by FRET-based Z'-Lyte assay | B | 8.37 | pIC50 | 4.25 | nM | IC50 | Medchemcomm (2012) 3: 1155-1159 |
| ChEMBL | Inhibition of GST-tagged human EGFR T790M/L858R double mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay | B | 8.4 | pIC50 | 4 | nM | IC50 | Eur J Med Chem (2017) 136: 497-510 [PMID:28528303] |
| ChEMBL | Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assay | B | 8.42 | pIC50 | 3.82 | nM | IC50 | J Med Chem (2013) 56: 7821-7837 [PMID:24053674] |
| ChEMBL | Inhibition of EGFR T790M mutant after 1.5 hr by FRET assay | B | 8.42 | pIC50 | 3.77 | nM | IC50 | J Med Chem (2012) 55: 2711-2723 [PMID:22339342] |
| ChEMBL | Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET based Z'-lyte assay | B | 8.49 | pIC50 | 3.2 | nM | IC50 | Eur J Med Chem (2013) 66: 82-90 [PMID:23792318] |
| ChEMBL | Inhibition of wild type EGFR (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assay | B | 8.49 | pIC50 | 3.2 | nM | IC50 | J Med Chem (2013) 56: 4738-4748 [PMID:23668441] |
| ChEMBL | Inhibition of recombinant human GST-tagged EGFR L858R/T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1257-1261 [PMID:29534926] |
| ChEMBL | Inhibition of N-terminal GST-tagged human recombinant EGFR L861Q mutant (668 to 1210 residues) expressed in baculovirus expression system by Z'-LYTE kinase assay | B | 8.54 | pIC50 | 2.86 | nM | IC50 | Eur J Med Chem (2021) 211: 113022-113022 [PMID:33239261] |
| ChEMBL | Inhibition of EGFR kinase T790M mutant (unknown origin) after 1.5 hrs by FRET-based Z'-Lyte assay | B | 8.61 | pIC50 | 2.47 | nM | IC50 | Medchemcomm (2012) 3: 1155-1159 |
| ChEMBL | Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assay | B | 8.67 | pIC50 | 2.16 | nM | IC50 | J Med Chem (2013) 56: 7821-7837 [PMID:24053674] |
| ChEMBL | Inhibition of N-terminal GST-tagged human recombinant EGFR T790M mutant (668 to 1210 residues) expressed in baculovirus expression system by Z'-LYTE kinase assay | B | 8.7 | pIC50 | 1.98 | nM | IC50 | Eur J Med Chem (2021) 211: 113022-113022 [PMID:33239261] |
| ChEMBL | Inhibition of EGFR L858R/T790M mutant after 1.5 hr by FRET assay | B | 8.73 | pIC50 | 1.88 | nM | IC50 | J Med Chem (2012) 55: 2711-2723 [PMID:22339342] |
| ChEMBL | Inhibition of EGFR kinase L858R/T790M double mutant (unknown origin) after 1.5 hrs by FRET-based Z'-Lyte assay | B | 8.74 | pIC50 | 1.82 | nM | IC50 | Medchemcomm (2012) 3: 1155-1159 |
| ChEMBL | Inhibition of EGFR (unknown origin) using biotin-labelled peptide as substrate preincubated for 2 hrs followed by substrate addition and measured after 30 mins by HTRF FRET assay | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (2019) 62: 5901-5919 [PMID:31145622] |
| ChEMBL | Inhibition of EGFR L858R mutant (unknown origin) | B | 8.96 | pIC50 | 1.1 | nM | IC50 | J Med Chem (2017) 60: 4636-4656 [PMID:28482151] |
| ChEMBL | Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant expressed in baculovirus expression system preincubated for 30 mins followed by ATP and TK-substrate addition measured after 20 mins by HTRF assay | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2017) 60: 7725-7744 [PMID:28853575] |
| ChEMBL | Inhibition of EGFR L858R mutant (unknown origin) expressed in Sf9 cells pre-incubated for 60 mins before substrate and ATP addition by homogeneous time-resolved FRET assay | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2015) 58: 6844-6863 [PMID:26275028] |
| ChEMBL | Inhibition of human N-terminal GST-fused EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated for 30 mins followed by substrate addition measured after 15 mins by HTFR assay | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2017) 60: 5613-5637 [PMID:28603991] |
| ChEMBL | Inhibition of human N-terminal GST-fused EGFR T790M/L858R double mutant (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated for 30 mins followed by substrate addition measured after 20 mins by HTFR assay | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2017) 60: 5613-5637 [PMID:28603991] |
| ChEMBL | Inhibition of human recombinant GST-tagged EGFR L858R mutant expressed in baculovirus expression system preincubated for 30 mins followed by ATP and TK-substrate addition measured after 15 mins by HTRF assay | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2017) 60: 7725-7744 [PMID:28853575] |
| ChEMBL | Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in Sf9 cells pre-incubated for 60 mins before substrate and ATP addition by homogeneous time-resolved FRET assay | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2015) 58: 6844-6863 [PMID:26275028] |
| ChEMBL | Inhibition of recombinant human N-terminal GST tagged EGFR L858R mutant (669 to 1210 residues) expressed in insect expression system using peptide as substrate incubated for 2 hrs followed by substrate addition and measured after 30 mins by TR-FRET assay | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Bioorg Med Chem (2018) 26: 1740-1750 [PMID:29523467] |
| ChEMBL | Inhibition of EGFR L858R/T790M mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET based Z'-lyte assay | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Eur J Med Chem (2013) 66: 82-90 [PMID:23792318] |
| ChEMBL | Inhibition of EGFR L858R/T90M double mutant (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assay | B | 9.1 | pIC50 | 0.8 | nM | IC50 | J Med Chem (2013) 56: 4738-4748 [PMID:23668441] |
| ChEMBL | Inhibition of EGFR L858R/T790M mutant (unknown origin) after 1.5 hr by FRET-based Z-lyte assay | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Eur J Med Chem (2014) 77: 75-83 [PMID:24607591] |
| ChEMBL | Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assay | B | 9.18 | pIC50 | 0.66 | nM | IC50 | J Med Chem (2013) 56: 7821-7837 [PMID:24053674] |
| ChEMBL | Inhibition of EGFR L858R/T790M double mutant (unknown origin) | B | 9.3 | pIC50 | <0.5 | nM | IC50 | J Med Chem (2017) 60: 4636-4656 [PMID:28482151] |
| ChEMBL | Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) L858R mutant expressed in Sf9 cells pre-incubated for 30 mins before ATP and substrate addition by homogeneous time-resolved FRET assay | B | 9.38 | pIC50 | 0.42 | nM | IC50 | Bioorg Med Chem (2015) 23: 2767-2780 [PMID:25975640] |
| ChEMBL | Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) T790M/L858R mutant expressed in Sf9 cells pre-incubated for 30 mins before ATP and substrate addition by homogeneous time-resolved FRET assay | B | 9.72 | pIC50 | 0.19 | nM | IC50 | Bioorg Med Chem (2015) 23: 2767-2780 [PMID:25975640] |
| ChEMBL | Inhibition of recombinant human N-terminal GST tagged EGFR L858R/T790M double mutant (669 to 1210 residues) expressed in insect expression system using peptide as substrate incubated for 2 hrs followed by substrate addition and measured after 30 mins by TR-FRET assay | B | 10.4 | pIC50 | 0.04 | nM | IC50 | Bioorg Med Chem (2018) 26: 1740-1750 [PMID:29523467] |
| ChEMBL | Inhibition of wild type EGFR (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | B | 6 | pEC50 | 989 | nM | EC50 | Eur J Med Chem (2017) 136: 497-510 [PMID:28528303] |
| ChEMBL | Inhibition of EGFR exon19 deletion mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | B | 7.17 | pEC50 | 68 | nM | EC50 | Eur J Med Chem (2017) 136: 497-510 [PMID:28528303] |
| ChEMBL | Inhibition of EGFR T790M/L858R double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | B | 7.51 | pEC50 | 31 | nM | EC50 | Eur J Med Chem (2017) 136: 497-510 [PMID:28528303] |
| ChEMBL | Inhibition of EGFR T790M exon19 deletion double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | B | 7.57 | pEC50 | 27 | nM | EC50 | Eur J Med Chem (2017) 136: 497-510 [PMID:28528303] |
| ChEMBL | Inhibition of EGFR L858R mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | B | 7.59 | pEC50 | 26 | nM | EC50 | Eur J Med Chem (2017) 136: 497-510 [PMID:28528303] |
| ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3099] [GtoPdb: 1923] [UniProtKB: P00520] | ||||||||
| ChEMBL | Inhibition of ABL T315I mutant in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assay | B | 4.79 | pIC50 | 16280 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 4832-4837 [PMID:28974338] |
| ChEMBL | Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assay | B | 5.01 | pIC50 | 9690 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 4832-4837 [PMID:28974338] |
| Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| ChEMBL | Binding affinity to JAK3 (unknown origin) | B | 6.82 | pKd | 150 | nM | Kd | J Med Chem (2015) 58: 6589-6606 [PMID:26258521] |
| erb-b2 receptor tyrosine kinase 4 in Human [GtoPdb: 1799] [UniProtKB: Q15303] | ||||||||
| GtoPdb | - | - | 7.55 | pKd | 28 | nM | Kd | Nature (2009) 462: 1070-4 [PMID:20033049] |
| BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451] | ||||||||
| GtoPdb | - | - | 6.7 | pKd | 200 | nM | Kd | Nature (2009) 462: 1070-4 [PMID:20033049] |
| Bruton tyrosine kinase in Human [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
| GtoPdb | - | - | 7.37 | pKd | 43 | nM | Kd | Nature (2009) 462: 1070-4 [PMID:20033049] |
| IL2 inducible T cell kinase in Human [GtoPdb: 2046] [UniProtKB: Q08881] | ||||||||
| GtoPdb | - | - | 7.37 | pKd | 43 | nM | Kd | Nature (2009) 462: 1070-4 [PMID:20033049] |
| NUAK family kinase 1 in Human [GtoPdb: 2129] [UniProtKB: O60285] | ||||||||
| GtoPdb | - | - | 7.04 | pKd | 91 | nM | Kd | Nature (2009) 462: 1070-4 [PMID:20033049] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
