adenosine 5'-monophosphate | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY

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adenosine 5'-monophosphate
Ligand Activity Charts

adenosine 5'-monophosphate [Ligand Id: 2455] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL752 (5'-adenylic acid, A 5MP, A-5MP, Adenosine Monophosphate, Adenosine phosphate, Adenyl, My-b-den, NSC-20264, Vitamin b8)
2`-deoxynucleoside 5`-phosphate N-hydrolase 1 in Human [ChEMBL: CHEMBL3351218] [UniProtKB: O43598] 2`-deoxynucleoside 5`-phosphate N-hydrolase 1 in Rat [ChEMBL: CHEMBL3329079] [UniProtKB: O35820] There should be some charts here, you may need to enable JavaScript!
A₁ receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] There should be some charts here, you may need to enable JavaScript!
Adenylate kinase 2 in Rat [ChEMBL: CHEMBL2376] [UniProtKB: P29410] There should be some charts here, you may need to enable JavaScript!
protein kinase AMP-activated non-catalytic subunit beta 2/protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit gamma 3/protein kinase AMP-activated non-catalytic subunit gamma 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, AMPK in Human [ChEMBL: CHEMBL2096907] [GtoPdb: 1544, 1545, 1542, 1541, 1547, 1546, 1543] [UniProtKB: O43741, P54619, P54646, Q13131, Q9UGI9, Q9UGJ0, Q9Y478] There should be some charts here, you may need to enable JavaScript!
protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 in Human [ChEMBL: CHEMBL2111345] [GtoPdb: 1545, 1541, 1543] [UniProtKB: P54619, Q13131, Q9Y478] There should be some charts here, you may need to enable JavaScript!
protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMPK alpha2/beta1/gamma1 in Human [ChEMBL: CHEMBL3038455] [GtoPdb: 1545, 1542, 1543] [UniProtKB: P54619, P54646, Q9Y478] There should be some charts here, you may need to enable JavaScript!
Fructose-1,6-bisphosphatase in Human [ChEMBL: CHEMBL3975] [UniProtKB: P09467] Fructose-1,6-bisphosphatase in Pig [ChEMBL: CHEMBL2263] [UniProtKB: P00636] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL243] [UniProtKB: Q72874] There should be some charts here, you may need to enable JavaScript!
Ketopantoate reductase in Escherichia coli K-12 [ChEMBL: CHEMBL4855] [UniProtKB: P0A9J4] There should be some charts here, you may need to enable JavaScript!
L-lactate dehydrogenase A chain in Human [ChEMBL: CHEMBL4835] [UniProtKB: P00338] There should be some charts here, you may need to enable JavaScript!
P2Y purinoceptor 1 in Turkey [ChEMBL: CHEMBL5720] [UniProtKB: P49652] There should be some charts here, you may need to enable JavaScript!
P2Y₁ receptor/Purinergic receptor P2Y1 in Human [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900] There should be some charts here, you may need to enable JavaScript!
P2Y₁₁ receptor/Purinergic receptor P2Y11 in Human [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91] There should be some charts here, you may need to enable JavaScript!
P2Y₂ receptor/Purinergic receptor P2Y2 in Human [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] There should be some charts here, you may need to enable JavaScript!
TRPM2/Transient receptor potential cation channel subfamily M member 2 in Human [ChEMBL: CHEMBL1250402] [GtoPdb: 494] [UniProtKB: O94759] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43] There should be some charts here, you may need to enable JavaScript!
AMP kinase in Human [GtoPdb: 1540] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
2`-deoxynucleoside 5`-phosphate N-hydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3351218] [UniProtKB: O43598]
ChEMBL	Inhibition of human DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically	B	4.72	pKi	19200	nM	Ki	Eur. J. Med. Chem. (2014) 85: 418-437 [PMID:25108359]
2`-deoxynucleoside 5`-phosphate N-hydrolase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3329079] [UniProtKB: O35820]
ChEMBL	Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically	B	4.4	pKi	40000	nM	Ki	Eur. J. Med. Chem. (2014) 85: 418-437 [PMID:25108359]
A₁ receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL	Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay	F	6.3	pEC50	500	nM	EC50	J. Med. Chem. (2012) 55: 6467-6477 [PMID:22738238]
Adenylate kinase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2376] [UniProtKB: P29410]
ChEMBL	Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP	B	4.1	pKi	80000	nM	Ki	J. Med. Chem. (1982) 25: 1179-1184 [PMID:6292418]
protein kinase AMP-activated non-catalytic subunit beta 2/protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit gamma 3/protein kinase AMP-activated non-catalytic subunit gamma 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, AMPK in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2096907] [GtoPdb: 1544, 1545, 1542, 1541, 1547, 1546, 1543] [UniProtKB: O43741, P54619, P54646, Q13131, Q9UGI9, Q9UGJ0, Q9Y478]
ChEMBL	Activation of human AMPK after 15 mins	B	5.23	pEC50	5900	nM	EC50	ACS Med. Chem. Lett. (2010) 1: 478-482 [PMID:24900234]
protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111345] [GtoPdb: 1545, 1541, 1543] [UniProtKB: P54619, Q13131, Q9Y478]
ChEMBL	Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assay	B	5.43	pKd	3700	nM	Kd	J Med Chem (2016) 59: 8068-8081 [PMID:27490827]
ChEMBL	Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphorylation preincubated for 15 mins followed by incubation with PP2a for 60 mins measured 60 mins post okadaic acid/Cy5-labelled SAMS and ATP addition by TR-FRET assay	B	5.82	pEC50	1519	nM	EC50	J Med Chem (2016) 59: 8068-8081 [PMID:27490827]
protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMPK alpha2/beta1/gamma1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038455] [GtoPdb: 1545, 1542, 1543] [UniProtKB: P54619, P54646, Q9Y478]
ChEMBL	Allosteric activation of AMPK alpha2/beta1/gamma1 in human HepG2 cells by scintillation proximity assay	B	5.85	pEC50	1400	nM	EC50	Bioorg Med Chem Lett (2020) 30: 126790-126790 [PMID:31744674]
Fructose-1,6-bisphosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3975] [UniProtKB: P09467]
ChEMBL	Inhibition of human liver fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase/glucose-6-phosphate dehydrogenase coupled assay	B	5.01	pIC50	9800	nM	IC50	Eur. J. Med. Chem. (2010) 45: 1478-1484 [PMID:20116906]
ChEMBL	Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) using FBP as substrate in presence of PGI and G6PDH by spectrophotometric method	B	5.48	pIC50	3300	nM	IC50	J Med Chem (2020) 63: 10307-10329 [PMID:32820629]
ChEMBL	Inhibition of human recombinant FBPase expressed in Escherichia coli BL21(DE3) by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coupled assay	B	5.49	pIC50	3200	nM	IC50	Bioorg. Med. Chem. (2014) 22: 1850-1862 [PMID:24530031]
ChEMBL	Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) Rosetta cells assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coupling based spectrophotometry	B	5.49	pIC50	3200	nM	IC50	Eur. J. Med. Chem. (2015) 90: 394-405 [PMID:25461330]
ChEMBL	Inhibition of human liver FBP1 incubated for 5 mins by fluorescence method	B	5.59	pIC50	2600	nM	IC50	J Nat Prod (2020) 83: 1541-1552 [PMID:32364726]
ChEMBL	Inhibition of wild-type full-length human liver FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate by malachite green dye based assay	B	5.64	pIC50	2300	nM	IC50	Eur J Med Chem (2020) 203: 112500-112500 [PMID:32711108]
ChEMBL	Inhibition of human FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green dye based spectrophotometry	B	5.64	pIC50	2300	nM	IC50	Eur J Med Chem (2019) 184: 111749-111749 [PMID:31589992]
ChEMBL	Inhibition of FBPase (unknown origin)	B	6	pIC50	1000	nM	IC50	MedChemComm (2011) 2: 287-290
ChEMBL	Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry	B	6	pIC50	1000	nM	IC50	J. Med. Chem. (2009) 52: 2880-2898 [PMID:19348494]
ChEMBL	Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.	B	6.1	pIC50	800	nM	IC50	Bioorg. Med. Chem. Lett. (2001) 11: 17-21 [PMID:11140724]
ChEMBL	Inhibition of FBPase in human liver	B	6.36	pIC50	440	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 594-599 [PMID:19969452]
ChEMBL	Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrate	B	6.85	pIC50	140	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 594-599 [PMID:19969452]
Fructose-1,6-bisphosphatase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2263] [UniProtKB: P00636]
ChEMBL	Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry	B	5.89	pIC50	1300	nM	IC50	Bioorg. Med. Chem. (2009) 17: 3916-3922 [PMID:19419876]
ChEMBL	Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase/glucose-6-phosphate dehydrogenase coupled assay	B	5.89	pIC50	1300	nM	IC50	Eur. J. Med. Chem. (2010) 45: 1478-1484 [PMID:20116906]
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874]
ChEMBL	Equilibrium constant for the interaction between inhibitor and HIV-1 Protease	B	8.95	pKd	1.13	nM	Kd	J. Med. Chem. (2002) 45: 5430-5439 [PMID:12459011]
ChEMBL	Inhibition constant against HIV-1 Protease	B	9.64	pKi	0.23	nM	Ki	J. Med. Chem. (2002) 45: 5430-5439 [PMID:12459011]
Ketopantoate reductase in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4855] [UniProtKB: P0A9J4]
ChEMBL	Binding affinity to Escherichia coli KPR	B	2.3	pKd	>5000000	nM	Kd	J. Med. Chem. (2006) 49: 4992-5000 [PMID:16884311]
ChEMBL	Inhibition of Escherichia coli KPR	B	2.2	pKi	6300000	nM	Ki	J. Med. Chem. (2006) 49: 4992-5000 [PMID:16884311]
L-lactate dehydrogenase A chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4835] [UniProtKB: P00338]
ChEMBL	Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by NMR analysis in presence of NADH	B	3.19	pKd	650000	nM	Kd	J. Med. Chem. (2012) 55: 3285-3306 [PMID:22417091]
ChEMBL	Inhibition of full length human recombinant LDHA expressed in Escherichia coli BL21 (DE3) cells after 10 mins by spectrophotometric analysis	B	3.3	pIC50	>500000	nM	IC50	J. Med. Chem. (2012) 55: 3285-3306 [PMID:22417091]
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652]
ChEMBL	Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cell	F	5.46	pEC50	3500	nM	EC50	J. Med. Chem. (2002) 45: 208-218 [PMID:11754592]
ChEMBL	Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cell	F	5.55	pEC50	2800	nM	EC50	J. Med. Chem. (2002) 45: 208-218 [PMID:11754592]
P2Y₁ receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900]
ChEMBL	Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cell	F	5.14	pEC50	7200	nM	EC50	J. Med. Chem. (2002) 45: 208-218 [PMID:11754592]
ChEMBL	Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cell	F	5.82	pEC50	1500	nM	EC50	J. Med. Chem. (2002) 45: 208-218 [PMID:11754592]
P2Y₁₁ receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91]
ChEMBL	Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM	F	4.76	pEC50	17250	nM	EC50	J. Med. Chem. (2002) 45: 208-218 [PMID:11754592]
P2Y₂ receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
ChEMBL	Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cell	F	5.43	pEC50	3700	nM	EC50	J. Med. Chem. (2002) 45: 208-218 [PMID:11754592]
ChEMBL	Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cell	F	7.07	pEC50	85	nM	EC50	J. Med. Chem. (2002) 45: 208-218 [PMID:11754592]
TRPM2/Transient receptor potential cation channel subfamily M member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250402] [GtoPdb: 494] [UniProtKB: O94759]
ChEMBL	Inhibition of TRPM2 (unknown origin)	B	4.15	pIC50	70000	nM	IC50	J. Med. Chem. (2013) 56: 10079-10102 [PMID:24304219]
ChEMBL	Inhibition of human TRPM2 assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiology method	B	4.15	pIC50	70000	nM	IC50	Eur J Med Chem (2018) 152: 235-252 [PMID:29723786]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of p60c-src expressed in chick embryo fibroblast	B	7	pIC50	100	nM	IC50	J. Nat. Prod. (1992) 55: 1529-1560 [PMID:1479375]
TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43]
GtoPdb	-	-	4.7	pIC50	-	-	-	Pflugers Arch (2004) 448: 70-5 [PMID:14758478]
AMP kinase in Human [GtoPdb: 1540]
GtoPdb	Activation of AMPK partially purified from HEK cells.	-	4.21	pEC50	61000	nM	EC50	Cell Metab (2006) 3: 403-16 [PMID:16753576]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]