adenosine 5'-monophosphate [Ligand Id: 2455] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL752 (5'-adenylic acid, A 5MP, A-5MP, Adenosine 5'-monophosphoric acid, Adenosine Monophosphate, Adenosine phosphate, NSC-20264, Vitamin b8) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 2`-deoxynucleoside 5`-phosphate N-hydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3351218] [UniProtKB: O43598] | ||||||||
| ChEMBL | Inhibition of human DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically | B | 4.72 | pKi | 19200 | nM | Ki | Eur J Med Chem (2014) 85: 418-437 [PMID:25108359] |
| 2`-deoxynucleoside 5`-phosphate N-hydrolase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3329079] [UniProtKB: O35820] | ||||||||
| ChEMBL | Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically | B | 4.4 | pKi | 40000 | nM | Ki | Eur J Med Chem (2014) 85: 418-437 [PMID:25108359] |
| A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| ChEMBL | Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay | F | 6.3 | pEC50 | 500 | nM | EC50 | J Med Chem (2012) 55: 6467-6477 [PMID:22738238] |
| Adenylate kinase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2376] [UniProtKB: P29410] | ||||||||
| ChEMBL | Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP | B | 4.1 | pKi | 80000 | nM | Ki | J Med Chem (1982) 25: 1179-1184 [PMID:6292418] |
| protein kinase AMP-activated non-catalytic subunit beta 2/protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit gamma 3/protein kinase AMP-activated non-catalytic subunit gamma 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, AMPK in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2096907] [GtoPdb: 1544, 1545, 1542, 1541, 1547, 1546, 1543] [UniProtKB: O43741, P54619, P54646, Q13131, Q9UGI9, Q9UGJ0, Q9Y478] | ||||||||
| ChEMBL | Activation of human AMPK after 15 mins | B | 5.23 | pEC50 | 5900 | nM | EC50 | ACS Med Chem Lett (2010) 1: 478-482 [PMID:24900234] |
| protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111345] [GtoPdb: 1545, 1541, 1543] [UniProtKB: P54619, Q13131, Q9Y478] | ||||||||
| ChEMBL | Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assay | B | 5.43 | pKd | 3700 | nM | Kd | J Med Chem (2016) 59: 8068-8081 [PMID:27490827] |
| ChEMBL | Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphorylation preincubated for 15 mins followed by incubation with PP2a for 60 mins measured 60 mins post okadaic acid/Cy5-labelled SAMS and ATP addition by TR-FRET assay | B | 5.82 | pEC50 | 1519 | nM | EC50 | J Med Chem (2016) 59: 8068-8081 [PMID:27490827] |
| protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMPK alpha2/beta1/gamma1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038455] [GtoPdb: 1545, 1542, 1543] [UniProtKB: P54619, P54646, Q9Y478] | ||||||||
| ChEMBL | Allosteric activation of AMPK alpha2/beta1/gamma1 in human HepG2 cells by scintillation proximity assay | B | 5.85 | pEC50 | 1400 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 126790-126790 [PMID:31744674] |
| Fructose-1,6-bisphosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3975] [UniProtKB: P09467] | ||||||||
| ChEMBL | Inhibition of human liver fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase/glucose-6-phosphate dehydrogenase coupled assay | B | 5.01 | pIC50 | 9800 | nM | IC50 | Eur J Med Chem (2010) 45: 1478-1484 [PMID:20116906] |
| ChEMBL | Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) using FBP as substrate in presence of PGI and G6PDH by spectrophotometric method | B | 5.48 | pIC50 | 3300 | nM | IC50 | J Med Chem (2020) 63: 10307-10329 [PMID:32820629] |
| ChEMBL | Inhibition of human recombinant FBPase expressed in Escherichia coli BL21(DE3) by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coupled assay | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem (2014) 22: 1850-1862 [PMID:24530031] |
| ChEMBL | Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) Rosetta cells assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coupling based spectrophotometry | B | 5.49 | pIC50 | 3200 | nM | IC50 | Eur J Med Chem (2015) 90: 394-405 [PMID:25461330] |
| ChEMBL | Inhibition of human liver FBP1 incubated for 5 mins by fluorescence method | B | 5.59 | pIC50 | 2600 | nM | IC50 | J Nat Prod (2020) 83: 1541-1552 [PMID:32364726] |
| ChEMBL | Inhibition of wild-type full-length human liver FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate by malachite green dye based assay | B | 5.64 | pIC50 | 2300 | nM | IC50 | Eur J Med Chem (2020) 203: 112500-112500 [PMID:32711108] |
| ChEMBL | Inhibition of human FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green dye based spectrophotometry | B | 5.64 | pIC50 | 2300 | nM | IC50 | Eur J Med Chem (2019) 184: 111749-111749 [PMID:31589992] |
| ChEMBL | Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry method | B | 6 | pIC50 | 1000 | nM | IC50 | Eur J Med Chem (2017) 141: 473-505 [PMID:29055870] |
| ChEMBL | Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2009) 52: 2880-2898 [PMID:19348494] |
| ChEMBL | Inhibition of FBPase (unknown origin) | B | 6 | pIC50 | 1000 | nM | IC50 | Medchemcomm (2011) 2: 287-290 |
| ChEMBL | Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase. | B | 6.1 | pIC50 | 800 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 17-21 [PMID:11140724] |
| ChEMBL | Inhibition of FBPase in human liver | B | 6.36 | pIC50 | 440 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 594-599 [PMID:19969452] |
| ChEMBL | Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrate | B | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 594-599 [PMID:19969452] |
| Fructose-1,6-bisphosphatase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2263] [UniProtKB: P00636] | ||||||||
| ChEMBL | Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2009) 17: 3916-3922 [PMID:19419876] |
| ChEMBL | Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase/glucose-6-phosphate dehydrogenase coupled assay | B | 5.89 | pIC50 | 1300 | nM | IC50 | Eur J Med Chem (2010) 45: 1478-1484 [PMID:20116906] |
| Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874] | ||||||||
| ChEMBL | Equilibrium constant for the interaction between inhibitor and HIV-1 Protease | B | 8.95 | pKd | 1.13 | nM | Kd | J Med Chem (2002) 45: 5430-5439 [PMID:12459011] |
| ChEMBL | Inhibition constant against HIV-1 Protease | B | 9.64 | pKi | 0.23 | nM | Ki | J Med Chem (2002) 45: 5430-5439 [PMID:12459011] |
| Ketopantoate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4855] [UniProtKB: P0A9J4] | ||||||||
| ChEMBL | Binding affinity to Escherichia coli KPR | B | 2.3 | pKd | >5000000 | nM | Kd | J Med Chem (2006) 49: 4992-5000 [PMID:16884311] |
| ChEMBL | Inhibition of Escherichia coli KPR | B | 2.2 | pKi | 6300000 | nM | Ki | J Med Chem (2006) 49: 4992-5000 [PMID:16884311] |
| L-lactate dehydrogenase A chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4835] [UniProtKB: P00338] | ||||||||
| ChEMBL | Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by NMR analysis in presence of NADH | B | 3.19 | pKd | 650000 | nM | Kd | J Med Chem (2012) 55: 3285-3306 [PMID:22417091] |
| ChEMBL | Inhibition of full length human recombinant LDHA expressed in Escherichia coli BL21 (DE3) cells after 10 mins by spectrophotometric analysis | B | 3.3 | pIC50 | >500000 | nM | IC50 | J Med Chem (2012) 55: 3285-3306 [PMID:22417091] |
| P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652] | ||||||||
| ChEMBL | Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cell | F | 5.46 | pEC50 | 3500 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| ChEMBL | Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cell | F | 5.55 | pEC50 | 2800 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| P2Y1 receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cell | F | 5.14 | pEC50 | 7200 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cell | F | 5.82 | pEC50 | 1500 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| P2Y11 receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91] | ||||||||
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM | F | 4.76 | pEC50 | 17250 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] | ||||||||
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cell | F | 5.43 | pEC50 | 3700 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cell | F | 7.07 | pEC50 | 85 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| TRPM2/Transient receptor potential cation channel subfamily M member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250402] [GtoPdb: 494] [UniProtKB: O94759] | ||||||||
| ChEMBL | Inhibition of TRPM2 (unknown origin) | B | 4.15 | pIC50 | 70000 | nM | IC50 | J Med Chem (2013) 56: 10079-10102 [PMID:24304219] |
| ChEMBL | Inhibition of human TRPM2 assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiology method | B | 4.15 | pIC50 | 70000 | nM | IC50 | Eur J Med Chem (2018) 152: 235-252 [PMID:29723786] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Inhibition of p60c-src expressed in chick embryo fibroblast | B | 7 | pIC50 | 100 | nM | IC50 | J Nat Prod (1992) 55: 1529-1560 [PMID:1479375] |
| TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43] | ||||||||
| GtoPdb | - | - | 4.7 | pIC50 | - | - | - | Pflugers Arch (2004) 448: 70-5 [PMID:14758478] |
| AMP kinase in Human [GtoPdb: 1540] | ||||||||
| GtoPdb | Activation of AMPK partially purified from HEK cells. | - | 4.21 | pEC50 | 61000 | nM | EC50 | Cell Metab (2006) 3: 403-16 [PMID:16753576] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
