ChEMBL ligand: CHEMBL3895863
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Human [ChEMBL: CHEMBL2189127] [GtoPdb: 2919] [UniProtKB: Q9BV23] αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Mouse [ChEMBL: CHEMBL5010] [GtoPdb: 2919] [UniProtKB: Q8R2Y0] There should be some charts here, you may need to enable JavaScript!
diacylglycerol lipase α/Sn1-specific diacylglycerol lipase alpha in Human [ChEMBL: CHEMBL5545] [GtoPdb: 1396] [UniProtKB: Q9Y4D2] diacylglycerol lipase α/Sn1-specific diacylglycerol lipase alpha in Mouse [ChEMBL: CHEMBL5180] [GtoPdb: 1396] [UniProtKB: Q6WQJ1] There should be some charts here, you may need to enable JavaScript!
diacylglycerol lipase β in Human [GtoPdb: 1397] [UniProtKB: Q8NCG7] diacylglycerol lipase β/Sn1-specific diacylglycerol lipase beta in Mouse [ChEMBL: CHEMBL5656] [GtoPdb: 1397] [UniProtKB: Q91WC9] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189127] [GtoPdb: 2919] [UniProtKB: Q9BV23]
ChEMBL	Inhibition of human recombinant ABHD6	B	8.55	pIC50	2.8	nM	IC50	Eur J Med Chem (2020) 198: 112353-112353 [PMID:32371333]
ChEMBL	Inhibition of human ABHD6 using 2-AG as natural substrate by fluorescence based assay	B	8.6	pIC50	2.51	nM	IC50	J Med Chem (2017) 60: 428-440 [PMID:27992221]
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5010] [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
ChEMBL	Inhibition of ABHD6 in mouse brain membrane using HT-01 probe as substrate incubated for 30 mins by gel based competitive ABPP assay	B	6.9	pIC50	126	nM	IC50	Eur J Med Chem (2020) 198: 112353-112353 [PMID:32371333]
ChEMBL	Inhibition of MB064 probe binding to ABHD6 in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured after 20 mins by gel-based competitive activity based protein profiling assay	B	7.1	pIC50	79.43	nM	IC50	J Med Chem (2017) 60: 428-440 [PMID:27992221]
diacylglycerol lipase α/Sn1-specific diacylglycerol lipase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5545] [GtoPdb: 1396] [UniProtKB: Q9Y4D2]
GtoPdb	-	-	8.2	pIC50	-	-	-	Proc Natl Acad Sci USA (2016) 113: 26-33 [PMID:26668358]
ChEMBL	Inhibition of full length recombinant human DAGLalpha expressed in HEK293T cell membranes using PNP butyrate as substrate by colorimetric assay	B	8.9	pIC50	1.26	nM	IC50	J Med Chem (2017) 60: 428-440 [PMID:27992221]
ChEMBL	Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe addition measured after 30 mins in presence of probe by gel-based ABPP competition assay	B	8.9	pIC50	1.26	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3831-3837 [PMID:27394666]
GtoPdb	-	-	8.9	pIC50	-	-	-	J Med Chem (2017) 60: 428-440 [PMID:27992221]
diacylglycerol lipase α/Sn1-specific diacylglycerol lipase alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5180] [GtoPdb: 1396] [UniProtKB: Q6WQJ1]
ChEMBL	Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes assessed as inhibition constant pre-incubated for 20 mins before PNP-butyrate substrate addition and measured after 30 mins by surrogate substrate assay	B	9.57	pKi	0.27	nM	Ki	J Med Chem (2019) 62: 7910-7922 [PMID:31437392]
ChEMBL	Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured after 30 mins by surrogate substrate assay	B	9	pIC50	<1	nM	IC50	J Med Chem (2019) 62: 7910-7922 [PMID:31437392]
ChEMBL	Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured after 20 mins by gel-based competitive activity based protein profiling assay	B	9.2	pIC50	0.63	nM	IC50	J Med Chem (2017) 60: 428-440 [PMID:27992221]
diacylglycerol lipase β in Human [GtoPdb: 1397] [UniProtKB: Q8NCG7]
GtoPdb	-	-	8.6	pIC50	-	-	-	Proc Natl Acad Sci USA (2016) 113: 26-33 [PMID:26668358]
diacylglycerol lipase β/Sn1-specific diacylglycerol lipase beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5656] [GtoPdb: 1397] [UniProtKB: Q91WC9]
ChEMBL	Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe addition measured after 30 mins in presence of probe by gel-based ABPP competition assay	B	8.3	pIC50	5.01	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3831-3837 [PMID:27394666]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]