sakuranetin [Ligand Id: 412] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL448297 (7-O-Methylnaringenin, Naringenin 7-Methyl Ether, Sakuranetin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] | ||||||||
| ChEMBL | Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method | B | 4.71 | pIC50 | 19550 | nM | IC50 | J Nat Prod (2011) 74: 2489-2496 [PMID:22148193] |
| TAS2R31/Taste receptor type 2 member 31 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034804] [GtoPdb: 674] [UniProtKB: P59538] | ||||||||
| GtoPdb | - | - | 5.26 | pIC50 | 5500 | nM | IC50 | J Agric Food Chem (2011) 59: 13117-21 [PMID:22059530] |
| ChEMBL | Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit | B | 5.44 | pIC50 | 3600 | nM | IC50 | J Nat Prod (2011) 74: 1539-1555 [PMID:21650152] |
| A1 receptor in Rat [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| GtoPdb | - | - | 5.1 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
| A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| GtoPdb | - | - | 4.4 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
| A3 receptor in Human [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| GtoPdb | - | - | 5.5 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
